JNK-1-IN-1
JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1.
For research use only. We do not sell to patients.
- CAS No.: 1262406-02-9
- Formula: C24H22N6S
- Molecular Weight:426.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
JNK1 |
In Vitro
JNK-1-IN-1 (Compound 2) has affinity for binding to Jnk1-u, p38α-u, ERK2-u in HepG2 human hepatoma cells with Kd values of 11, 18, 18, respectively[1].
JNK-1-IN-1 inhibits MKK7cp in HepG2 human hepatoma cells with IC50 values of 7.8.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1262406-02-9
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Molecular Weight 426.54
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Formula C24H22N6S
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SMILES
CCCN(C1=NC(C=CC=C2)=C2S1)CC(C=C3)=CC=C3C4=CC=CC=C4C5=NNN=N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK-1-IN-1 Related Classifications
HY-14411 Related Classifications
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