ZKSCAN8 - zinc finger with KRAB and SCAN domains 8 Gene

Also Known as LD5-1; ZNF192; ZSCAN40

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7745

About ZKSCAN8

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:28,141,635-28,159,460 (from NCBI)

This gene has 4 transcripts (splice variants), 94 orthologues and 31 paralogues. Ubiquitous expression in endometrium (RPKM 9.3), ovary (RPKM 8.6) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZKSCAN8 Products (4)

mRNA Protein Name
NM_001278119.2 NP_001265048.1 zinc finger protein with KRAB and SCAN domains 8 isoform 1
NM_001278121.2 NP_001265050.1 zinc finger protein with KRAB and SCAN domains 8 isoform 2
NM_001278122.2 NP_001265051.1 zinc finger protein with KRAB and SCAN domains 8 isoform 2
NM_006298.4 NP_006289.2 zinc finger protein with KRAB and SCAN domains 8 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZKSCAN8 Protein Structure

SCAN

SCAN: SCAN domain (47 - 134)

KRAB

KRAB: KRAB box (222 - 259)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (322 - 335)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (337 - 361)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (364 - 388)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (396 - 416)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (424 - 445)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (452 - 472)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (480 - 500)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (505 - 527)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (533 - 555)

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  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

zinc finger protein with KRAB and SCAN domains 8

  • zinc finger protein 192

ZKSCAN8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZKSCAN8 Q15776 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32296183
Intra
ZKSCAN8 Q15776 PPIA Homo sapiens P62937-2
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 PPIA Homo sapiens P62937-2
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 PPIA Homo sapiens P62937-2
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
ZKSCAN8 Q15776 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
ZKSCAN8 Q15776 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
ZKSCAN8 Q15776 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
ZKSCAN8 Q15776 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16083 ZKSCAN8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZKSCAN8 MGD MGI:1913815
Rattus norvegicus ZKSCAN8 RGD RGD:1308983
Canis familiaris ZKSCAN8 VGNC VGNC:49668
Bos taurus ZKSCAN8 VGNC VGNC:107041
Felis catus ZKSCAN8 VGNC VGNC:67250
Macaca mulatta ZKSCAN8 VGNC VGNC:78417
Others ZKSCAN8 NCBI