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Cat. No.: HY-111051

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JN403

JN403 is an orally active and selective α7 nicotinic acetylcholine receptor agonist. JN403 can be used in the study of central nervous system disorders.

For research use only. We do not sell to patients.

CAS No.: 942606-12-4
Formula: C₁₆H₂₁FN₂O₂
Molecular Weight:292.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JN403 Chemical Structure

CAS No.: 942606-12-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JN403 is an orally active and selective α7 nicotinic acetylcholine receptor agonist. JN403 can be used in the study of central nervous system disorders^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
GH3	EC₅₀	100 nM Compound: 30, JN403	Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assay Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assay	[PMID: 21919481]
Oocyte	EC₅₀	2 μM Compound: 30, JN403	Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward current Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward current	[PMID: 21919481]

Chemical Information

CAS No. 942606-12-4
Molecular Weight 292.35
Formula C₁₆H₂₁FN₂O₂
SMILES

C[C@@H](C1=C(C=CC=C1)F)OC(N[C@H]2C3CCN(CC3)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Feuerbach D, et al. The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology. 2009 Jan;56(1):254-63.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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