m-PEG12-amine
Based on 1 Customer Validation
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 1977493-48-3
- Formula: C25H53NO12
- Molecular Weight:559.69
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Non-cleavable Linker |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1977493-48-3
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Appearance Solid
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Molecular Weight 559.69
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Formula C25H53NO12
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Color Colorless to off-white
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SMILES
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (178.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. [Content Brief]
[2]. Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7867 mL | 8.9335 mL | 17.8670 mL | 44.6676 mL |
| 5 mM | 0.3573 mL | 1.7867 mL | 3.5734 mL | 8.9335 mL | |
| 10 mM | 0.1787 mL | 0.8934 mL | 1.7867 mL | 4.4668 mL | |
| 15 mM | 0.1191 mL | 0.5956 mL | 1.1911 mL | 2.9778 mL | |
| 20 mM | 0.0893 mL | 0.4467 mL | 0.8934 mL | 2.2334 mL | |
| 25 mM | 0.0715 mL | 0.3573 mL | 0.7147 mL | 1.7867 mL | |
| 30 mM | 0.0596 mL | 0.2978 mL | 0.5956 mL | 1.4889 mL | |
| 40 mM | 0.0447 mL | 0.2233 mL | 0.4467 mL | 1.1167 mL | |
| 50 mM | 0.0357 mL | 0.1787 mL | 0.3573 mL | 0.8934 mL | |
| 60 mM | 0.0298 mL | 0.1489 mL | 0.2978 mL | 0.7445 mL | |
| 80 mM | 0.0223 mL | 0.1117 mL | 0.2233 mL | 0.5583 mL | |
| 100 mM | 0.0179 mL | 0.0893 mL | 0.1787 mL | 0.4467 mL |
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