2-Hydroxyphenylethanol
Based on 1 Customer Validation
2-Hydroxyphenylethanol is a molecular chaperone that rescues misfolded P123S mutant pendrin, promoting translocation from the cytoplasm to the plasma membrane. 2-Hydroxyphenylethanol can be used for the research of pendred syndrome.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 7768-28-7
- 分子式: C8H10O2
- 分子量:138.17
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保管条件:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>15 mM
Compound: 18
|
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
|
[PMID: 28341401] |
| HEK293 | IC50 |
15 mM
Compound: 18
|
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
|
[PMID: 28341401] |
2-Hydroxyphenylethanol (Compound 18) (1-30 mM; 12 h) possesses significant molecular chaperone activity to rescue P123S mutant pendrin localization in stable HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 7768-28-7
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性状 Viscous Liquid
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分子量 138.17
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分子式 C8H10O2
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SMILES
OC=1C=CC=CC1CCO
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
純度とドキュメンテーション
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データシート (267 KB)
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SDS (614 KB)
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- Italian - IT (614 KB)
- Korean - KR (614 KB)
- Portuguese - PT (614 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)