2MD
2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 213250-70-5
- 分子式: C27H44O3
- 分子量:416.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | ED50 |
0.08 nM
Compound: 2, 2MD
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Induction of human HL60 cell differentiation after 4 days by NBT reduction assay
Induction of human HL60 cell differentiation after 4 days by NBT reduction assay
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[PMID: 22490010] |
| HL-60 | ED50 |
1.5 x 10-10M
Compound: 6b
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Induced differentiation of human promyelocyte HL-60 cells into monocytes
Induced differentiation of human promyelocyte HL-60 cells into monocytes
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[PMID: 9804706] |
2MD (0.5-10 ng/kg, 0,1 mL/day; p.o.; once daily for 16 weeks) not only restores both trabecular and cortical bone mass, but also increases bone mass and strength in osteopenic ovariectomized (OVX) rats by stimulating bone formation on the periosteal surface and decreasing bone resorption on the trabecular surface in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovariectomized (OVX) rats model (Sprague-Dawley female rats; 4-month-old)[2]
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Dosage:0.5, 1, 2.5, 5, and 10 ng/kg, 0,1 mL/day
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Administration:Oral gavage; once daily for 16 weeks
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Result:Significantly increased serum calcium at 2.5, 5, or 10 ng/kg/day.
Dose-dependent reduction in osteoclast number and trabecular osteoclast surface, and dose-dependent increased in periosteal bone formation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 213250-70-5
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分子量 416.64
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分子式 C27H44O3
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C([C@@H](C\3)O)=C)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518(1):53-60. [Content Brief]
[2]. Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20(10):1742-55. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
2MD 関連分類
HY-148698 関連分類
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