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製品番号: HY-13537

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BPR1J-097

Name: BPR1J-097
Brand: MedChemExpress
SKU: HY-13537
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

BPR1J-097 is a novel potent FLT3 inhibitor with an IC₅₀ of 11 nM.

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CAS 番号: 1327167-19-0
分子式: C₂₇H₂₈N₆O₃S
分子量:516.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BPR1J-097 構造式

CAS 番号: 1327167-19-0

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

BPR1J-097 is a novel potent FLT3 inhibitor with an IC₅₀ of 11 nM.

IC₅₀ & Target

IC50: 11 nM (FLT3)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	GI₅₀	0.012 μM Compound: 8f	Antiproliferation activity against human MOLM13 cells expressing FLT3 mutation assessed as cell viability after 72 hrs by MTS method Antiproliferation activity against human MOLM13 cells expressing FLT3 mutation assessed as cell viability after 72 hrs by MTS method	[PMID: 21708468]
MOLM-13	GI₅₀	0.021 μM Compound: 4	Cytotoxicity against human MOLM13 cells harboring mutant FLT3 after 72 hrs by MTS assay Cytotoxicity against human MOLM13 cells harboring mutant FLT3 after 72 hrs by MTS assay	[PMID: 23618709]
Sf9	IC₅₀	0.011 μM Compound: 4	Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysis Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.013 μM Compound: 8f	Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.13 μM Compound: 4	Inhibition of recombinant GST tagged VEGFR2 (789 to 1356) (unknown origin) transfected in insect sf9 cells after 120 mins by wallac counting analysis Inhibition of recombinant GST tagged VEGFR2 (789 to 1356) (unknown origin) transfected in insect sf9 cells after 120 mins by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.13 μM Compound: 8f	Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.21 μM Compound: 8f	Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.34 μM Compound: 4	Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting analysis Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.34 μM Compound: 8f	Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay	[PMID: 21708468]

化学情報

CAS 番号 1327167-19-0
分子量 516.61
分子式 C₂₇H₂₈N₆O₃S
SMILES

O=C(NC1=NNC(C2=CC=CC(NS(=O)(C3=CC=CC=C3)=O)=C2)=C1)C4=CC=C(N5CCN(C)CC5)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Cell Rep

A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]

2025 Nov 25;44(11):116496. PMID: 41166305

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lin WH, et al. BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML. Br J Cancer. 2012 Jan 31;106(3):475-81. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

BPR1J-097

1 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
Publications (1)
純度とドキュメンテーション
参考文献

製品名:
製品番号:
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BPR1J-097

UNC2025

MRX-2843

Gilteritinib

Quizartinib

SKLB4771

Denfivontinib

TCS 359

Gilteritinib hemifumarate

Tandutinib

FLT3-IN-3

UNC2025 hydrochloride

Gilteritinib (Standard)

MedChemExpress（MCE）の使用を引用している文献 BPR1J-097

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

BPR1J-097

UNC2025

MRX-2843

Gilteritinib

Quizartinib

SKLB4771

Denfivontinib

TCS 359

Gilteritinib hemifumarate

Tandutinib

FLT3-IN-3

UNC2025 hydrochloride

Gilteritinib (Standard)

MedChemExpress（MCE）の使用を引用している文献 BPR1J-097

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

BPR1J-097 関連分類

HY-13537 関連分類

Bioz