CAY 10465
Based on 1 publication(s) in Google Scholar
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.75%
- CAS 番号: 688348-33-6
- 分子式: C15H9Cl2F3
- 分子量:317.13
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 CAY 10465
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生物活性
Ki: 0.2 nM (AhR)[1]
CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 688348-33-6
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性状 Solid
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分子量 317.13
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分子式 C15H9Cl2F3
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Color White to off-white
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SMILES
FC(C1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion. [Abstract]2026 Jan 15;33(1):91-101.e12. PMID: 41483807
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (315.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. [Content Brief]
[2]. Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1533 mL | 15.7664 mL | 31.5328 mL | 78.8320 mL |
| 5 mM | 0.6307 mL | 3.1533 mL | 6.3066 mL | 15.7664 mL | |
| 10 mM | 0.3153 mL | 1.5766 mL | 3.1533 mL | 7.8832 mL | |
| 15 mM | 0.2102 mL | 1.0511 mL | 2.1022 mL | 5.2555 mL | |
| 20 mM | 0.1577 mL | 0.7883 mL | 1.5766 mL | 3.9416 mL | |
| 25 mM | 0.1261 mL | 0.6307 mL | 1.2613 mL | 3.1533 mL | |
| 30 mM | 0.1051 mL | 0.5255 mL | 1.0511 mL | 2.6277 mL | |
| 40 mM | 0.0788 mL | 0.3942 mL | 0.7883 mL | 1.9708 mL | |
| 50 mM | 0.0631 mL | 0.3153 mL | 0.6307 mL | 1.5766 mL | |
| 60 mM | 0.0526 mL | 0.2628 mL | 0.5255 mL | 1.3139 mL | |
| 80 mM | 0.0394 mL | 0.1971 mL | 0.3942 mL | 0.9854 mL | |
| 100 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7883 mL |
CAY 10465 関連分類
HY-112627 関連分類
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