Centanafadine
Based on 1 Customer Validation
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.62%
- CAS 番号: 924012-43-1
- 分子式: C15H15N
- 分子量:209.29
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 6 nM (human NE), 38 nM (human DA), 83 nM (human serotonin)[1].
Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters with IC50 values of 6 and 38 nM, respectively, for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT with an IC50 value of 83 nM [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 924012-43-1
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性状 Solid
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分子量 209.29
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分子式 C15H15N
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Color White to off-white
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SMILES
[C@@H]12[C@@](CNC2)(C3=CC(C=CC=C4)=C4C=C3)C1
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別名
EB-1020
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 125 mg/mL (597.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7781 mL | 23.8903 mL | 47.7806 mL | 119.4515 mL |
| 5 mM | 0.9556 mL | 4.7781 mL | 9.5561 mL | 23.8903 mL | |
| 10 mM | 0.4778 mL | 2.3890 mL | 4.7781 mL | 11.9451 mL | |
| 15 mM | 0.3185 mL | 1.5927 mL | 3.1854 mL | 7.9634 mL | |
| 20 mM | 0.2389 mL | 1.1945 mL | 2.3890 mL | 5.9726 mL | |
| 25 mM | 0.1911 mL | 0.9556 mL | 1.9112 mL | 4.7781 mL | |
| 30 mM | 0.1593 mL | 0.7963 mL | 1.5927 mL | 3.9817 mL | |
| 40 mM | 0.1195 mL | 0.5973 mL | 1.1945 mL | 2.9863 mL | |
| 50 mM | 0.0956 mL | 0.4778 mL | 0.9556 mL | 2.3890 mL | |
| 60 mM | 0.0796 mL | 0.3982 mL | 0.7963 mL | 1.9909 mL | |
| 80 mM | 0.0597 mL | 0.2986 mL | 0.5973 mL | 1.4931 mL | |
| 100 mM | 0.0478 mL | 0.2389 mL | 0.4778 mL | 1.1945 mL |
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