KAT681
KAT681 is a liver-selective thyromimetic.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 373641-87-3
- 分子式: C24H21FNNaO6
- 分子量:461.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-12216
ResmetiromTHR-β Agonist -
HY-14823
SobetiromeTRβ Agonist -
HY-10473
Eprotirome -
HY-111443
TR antagonist 1Thyroid Hormone Receptor Antagonist -
HY-A0070
Liothyronine sodiumTRα/TRβ Agonist -
HY-B1201
TiratricolThyroid Hormone Receptor Inhibitor -
HY-A0070R
Liothyronine sodium (Standard)TRα/TRβ Agonist -
HY-18341A
L-Thyroxine sodium salt pentahydrateThyroid Hormone -
HY-14823G
Sobetirome (GMP)TRβ Agonist -
HY-14823R
Sobetirome (Standard)TRβ Agonist -
HY-B0208
MethimazoleAnti-thyroid Agent -
HY-10473R
Eprotirome (Standard)Reference Standard
生物活性
製品説明
IC50 & Target
Thyroid Hormone Receptor[1]
体外実験
The impact of the liver-selective thyromimetic KAT681 (T-0681) is investigated on lipoprotein metabolism. Prolonged treatment with KAT681 increases the hepatic expression of both low-density lipoprotein (LDL) receptor and scavenger receptor class B, type I without affecting cholesteryl ester transfer protein activity. Western blot showing human SR-BI (CLA-1) expression in normal HepG2 cells and in HepG2 cells loaded with AcLDL and subsequently incubated with vehicle or KAT681. SR-BI protein expression is markedly downregulated by incubation with 50 μg/mL AcLDL. This effect can not be reversed by addition of KAT681[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 373641-87-3
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分子量 461.41
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分子式 C24H21FNNaO6
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SMILES
O=C(CC(NC1=CC(C)=C(C(C)=C1)OC2=CC=C(C(C(O)C3=CC=C(C=C3)F)=C2)O)=O)O[Na]
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別名
T0681
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tancevski I, et al. The thyromimetic T-0681 protects from atherosclerosis. J Lipid Res. 2009 May;50(5):938-44. [Content Brief]
[2]. Tancevski I, et al. The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice. PLoS One. 2010 Jan 15;5(1):e8722. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KAT681 関連分類
HY-U00220 関連分類
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