KAT681
KAT681 is a liver-selective thyromimetic.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 373641-87-3
- 分子式: C24H21FNNaO6
- 分子量:461.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-12216
ResmetiromTHR-β Agonist -
HY-14823
SobetiromeTRβ Agonist -
HY-10473
Eprotirome -
HY-111443
TR antagonist 1Thyroid Hormone Receptor Antagonist -
HY-A0070
Liothyronine sodiumTRα/TRβ Agonist -
HY-B1201
TiratricolThyroid Hormone Receptor Inhibitor -
HY-A0070R
Liothyronine sodium (Standard)TRα/TRβ Agonist -
HY-18341A
L-Thyroxine sodium salt pentahydrateThyroid Hormone -
HY-14823G
Sobetirome (GMP)TRβ Agonist -
HY-14823R
Sobetirome (Standard)TRβ Agonist -
HY-B0208
MethimazoleAnti-thyroid Agent -
HY-10473R
Eprotirome (Standard)Reference Standard
生物活性
製品説明
IC50 & Target
Thyroid Hormone Receptor[1]
体外実験
The impact of the liver-selective thyromimetic KAT681 (T-0681) is investigated on lipoprotein metabolism. Prolonged treatment with KAT681 increases the hepatic expression of both low-density lipoprotein (LDL) receptor and scavenger receptor class B, type I without affecting cholesteryl ester transfer protein activity. Western blot showing human SR-BI (CLA-1) expression in normal HepG2 cells and in HepG2 cells loaded with AcLDL and subsequently incubated with vehicle or KAT681. SR-BI protein expression is markedly downregulated by incubation with 50 μg/mL AcLDL. This effect can not be reversed by addition of KAT681[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 373641-87-3
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分子量 461.41
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分子式 C24H21FNNaO6
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SMILES
O=C(CC(NC1=CC(C)=C(C(C)=C1)OC2=CC=C(C(C(O)C3=CC=C(C=C3)F)=C2)O)=O)O[Na]
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別名
T0681
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tancevski I, et al. The thyromimetic T-0681 protects from atherosclerosis. J Lipid Res. 2009 May;50(5):938-44. [Content Brief]
[2]. Tancevski I, et al. The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice. PLoS One. 2010 Jan 15;5(1):e8722. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KAT681 関連分類
HY-U00220 関連分類
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