Cancer (がん)
Cancer therapy has always been the focus of biomedical research and practice across the world. Cancer is a disease in which mutations or genomic changes enable cells to achieve a wide range of abilities in order to escape apoptosis and growth inhibition signals, resulting in unlimited cells growth and spread to other parts of the body. It is characterized by uncontrolled proliferation of abnormal cells and abnormal recognition of the immune system. There are different treatments for cancer, depending on its progress, the type of cancer, the types of treatments available, and the target of treatment. Surgery, chemotherapy (CT) and radiotherapy (RT) are the three main methods to treat cancer in the traditional way. However, these treatments are potentially toxic and may cause side effects and multidrug resistance. Although cancer therapy can prolong the life of patients, yet a large number of patients still die because of cancer recurrence, hence the research on cancer recurrence and metastasis has always been the focus in the field of clinical medicine. According to different nature of therapies, the types of cancer treatment can be divided into the following categories.
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Cancer Targeted Therapy (45868)
Cancer targeted therapy is the foundation of precision medicine; it uses drugs or other substances to target specific genes and proteins that control cancer cells’ growth, division and spreading. -
Cancer Immunotherapy (14145)
Cancer immunotherapy (CIT) is a type of biological therapy, aiming to improve anti-tumor immune responses with fewer off-target effects than chemotherapy. -
Cancer Stem Cells (3373)
Cancer stem cells (CSCs) are populations of cancer cells that have the properties of stem cells i.e. self-renewal and ability to generate differentiated progenies. -
Cancer Drug Resistance (2255)
Drug resistance in chemotherapy, radiotherapy, molecular targeted therapy and immunotherapy is one of the main causes of death due to cancer. -
Cancer Metabolism and Metastasis (52880)
Metabolic abnormalities are a major feature of cancer, such as increased substance anabolic pathways and aerobic glycolysis.
References:
- [1] Larsen BD, et al. Science. 2022; 376(6592):476-483.
- [2] Ushijima T, et al. Science. 2021; 373(6562):1474-1479.
- [3] Shen S, et al. Cell. 2020; 183(4):860-874.
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Cell Proliferation Compound Library3,685 compoundsHY-L201
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癌幹細胞化合物ライブラリ3,582 compoundsHY-L135
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Anti-Brain Cancer Compound Library2,148 compoundsHY-L188
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抗卵巣癌化合物ライブラリ3,011 compoundsHY-L173
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抗胃癌化合物ライブラリ1,225 compoundsHY-L184
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抗癌化合物ライブラリ11,280 compoundsHY-L025
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抗がん代謝化合物ライブラリ3,849 compoundsHY-L083
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抗癌天然物ライブラリ2,049 compoundsHY-L107
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標的治療薬ライブラリ107 compoundsHY-L080
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血管新生関連化合物ライブラリ3,715 compoundsHY-L088
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抗肺癌化合物ライブラリ3,099 compoundsHY-L075
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抗乳癌化合物ライブラリ3,445 compoundsHY-L074
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抗膵臓がん化合物ライブラリ4,389 compoundsHY-L077
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抗肝臓がん化合物ライブラリ3,042 compoundsHY-L101
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抗大腸がん化合物ライブラリ2,699 compoundsHY-L103
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FDA承認抗癌薬ライブラリ1,545 compoundsHY-L122
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抗前立腺がん化合物ライブラリ3,708 compoundsHY-L124
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Chemotherapy Drug Library156 compoundsHY-L112
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腫瘍形成関連化合物ライブラリ147 compoundsHY-L100