Tritoqualine
Tritoqualine is a histidine decarboxylase inhibitor, that inhibits the release of histidine.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 14504-73-5
- 分子式: C26H32N2O8
- 分子量:500.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
histidine decarboxylase[1]
体外実験
The effect of Tritoqualine (TRQ) on the CCl4-induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl4. Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl4-stimulated lipid peroxidation at a concentration of 33 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 14504-73-5
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分子量 500.54
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分子式 C26H32N2O8
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SMILES
O=C1OC(C2N(C)CCC3=C2C(OC)=C(OCO4)C4=C3)C5=C1C(N)=C(OCC)C(OCC)=C5OCC
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別名
Inhibostamin; Hypostamine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ishii K, et al. Therapeutic effect of histidine decarboxylase inhibitor on chronic active hepatitis. Gastroenterol Jpn. 1978;13(2):105-10. [Content Brief]
[2]. Yuasa S, et al. Suppressive effect of tritoqualine on lipid peroxidation and enzyme leakage induced by carbon tetrachloride in rat hepatocytes. Jpn J Pharmacol. 1986 Jun;41(2):205-10. [Content Brief]
[3]. Umezu K, et al. Inhibitory effect of tritoqualine (TRQ) on histamine release from mast cells. Jpn J Pharmacol. 1985 Jun;38(2):153-60. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tritoqualine 関連分類
HY-U00065 関連分類
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