ADTL-EI1712
ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo.
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- CAS 番号: 2414916-45-1
- 分子式: C22H18Cl2N4O2S2
- 分子量:505.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>50 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
| HL-60 | IC50 |
1.26 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
| MKN-74 | IC50 |
2.55 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
ADTL-EI1712 shows antiproliferative activity against HL-60, MKN-74 and HeLa cells, with IC50 values of 1.26+0.57, 2.55+0.66, >50 μM, respectively[1].
ADTL-EI1712 (0.5 μM, 24 h) induces regulated cell death accompanied by autophagy in MKN-74 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2414916-45-1
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分子量 505.44
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分子式 C22H18Cl2N4O2S2
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SMILES
O=C(C1=C(NC(C2=CC=CC=C2Cl)=O)SC3=C1CCN(C(NC4=CC=CC=C4Cl)=S)C3)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ADTL-EI1712 関連分類
HY-138215 関連分類
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