Valiltramiprosate
Based on 1 publication(s) in Google Scholar
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.83%
- CAS 番号: 1034190-08-3
- 分子式: C8H18N2O4S
- 分子量:238.30
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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MedChemExpress（MCE）の使用を引用している文献 Valiltramiprosate
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生物活性
製品説明
IC50 & Target
β-amyloid[1]
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1034190-08-3
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性状 Solid
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分子量 238.30
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分子式 C8H18N2O4S
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Color White to off-white
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SMILES
O=S(CCCNC([C@@H](N)C(C)C)=O)(O)=O
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別名
ALZ-801
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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FASEB J
ALZ-801 prevents amyloid β-protein assembly and reduces cytotoxicity: A preclinical experimental study. [Abstract]2025 Feb 15;39(3):e70382. PMID: 39921439
溶剤 & 溶解度
体外:
H2O : 30 mg/mL (125.89 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (419.64 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
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取扱説明書 (2659 KB)
参考文献
ホットトピック
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Topics
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Most Recent
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Oldest
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Topics Aβ Deposition: The "First Trigger" in the Pathogenesis of AD and Decoding its Molecular Mechanism
β-amyloid (Aβ) deposition is considered a key early event in the development of Alzheimer's disease (AD).
2026-01-26
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.1964 mL | 20.9820 mL | 41.9639 mL | 104.9098 mL |
| 5 mM | 0.8393 mL | 4.1964 mL | 8.3928 mL | 20.9820 mL | |
| 10 mM | 0.4196 mL | 2.0982 mL | 4.1964 mL | 10.4910 mL | |
| 15 mM | 0.2798 mL | 1.3988 mL | 2.7976 mL | 6.9940 mL | |
| 20 mM | 0.2098 mL | 1.0491 mL | 2.0982 mL | 5.2455 mL | |
| 25 mM | 0.1679 mL | 0.8393 mL | 1.6786 mL | 4.1964 mL | |
| 30 mM | 0.1399 mL | 0.6994 mL | 1.3988 mL | 3.4970 mL | |
| 40 mM | 0.1049 mL | 0.5245 mL | 1.0491 mL | 2.6227 mL | |
| 50 mM | 0.0839 mL | 0.4196 mL | 0.8393 mL | 2.0982 mL | |
| 60 mM | 0.0699 mL | 0.3497 mL | 0.6994 mL | 1.7485 mL | |
| 80 mM | 0.0525 mL | 0.2623 mL | 0.5245 mL | 1.3114 mL | |
| 100 mM | 0.0420 mL | 0.2098 mL | 0.4196 mL | 1.0491 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Valiltramiprosate 関連分類
HY-117259 関連分類
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