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製品番号: HY-N10062

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Amakusamine

Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

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CAS 番号: 2923661-84-9
分子式: C₉H₅Br₂NO₂
分子量:318.95

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Amakusamine 構造式

CAS 番号: 2923661-84-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	10.5 μM Compound: 1; natural	Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay	[PMID: 34612636]
RAW264.7	IC₅₀	9.4 μM Compound: 1; Synthetic	Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay	[PMID: 34612636]

化学情報

CAS 番号 2923661-84-9
分子量 318.95
分子式 C₉H₅Br₂NO₂
SMILES

BrC1=C2OCOC2=C(C3=C1C=CN3)Br
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Plants
- other families
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Maeyama Y, et al. Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts. J Nat Prod. 2021 Oct 22;84(10):2738-2743. [Content Brief]

Calculators

モル濃度計算機

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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