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United States

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製品番号: HY-151401

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Antimicrobial agent-7

Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₆H₅₆N₂₄
分子量:824.99

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Antimicrobial agent-7 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Antimicrobial agent-7 (2.8-56.4 μM; 24 h) inhibits Gram-negative bacteria and Gram-positive bacteria growth^[1].
Antimicrobial agent-7 (5 and 20 μg/mL; 18 h) inhibits the production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) by lipopolysaccharide-stimulated in RAW 264.7 cells^[1].
Antimicrobial agent-7 exhibits proteolytic resistance and salt/serum stability^[1].
Antimicrobial agent-7 displays synergistic or additive effects when combined with selected clinically used antibiotics^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
Concentration:

2.8-56.4 μM
Incubation Time:

24 hours
Result:

Inhibited Gram-negative bacteria with MIC values of 17.7 and 4.8 μM for E. coli [KCTC 1682] and P. aeruginosa [KCTC 1637], respectively.
Inhibited Gram- positive bacteria with MIC values of 4.8 μM for S. epidermidis [KCTC 1917] and S. aureus [KCTC1621].

Cell Viability Assay^[1]

Cell Line:

RAW 264.7 macrophages
Concentration:

5 and 20 μg/mL
Incubation Time:

18 hours
Result:

Observed LPS-stimulated production of NO with an inhibitory rate of 68.09% at 5 μg/mL.
Exhibited inhibitory effects on the LPS-stimulated production of TNF-α with an inhibitory rate of 99.83% at 20 μg/mL.

化学情報

分子量 824.99
分子式 C₃₆H₅₆N₂₄
SMILES

NC(NCCNC1=NC(NCCNC(N)=N)=NC(N(C(CN2C3=NC(NCCNC(N)=N)=NC(NCCNC(N)=N)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1)=N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Dinesh Kumar S, et al. Cationic, amphipathic small molecules based on a triazine-piperazine-triazine scaffold as a new class of antimicrobial agents. Eur J Med Chem. 2022 Sep 8;243:114747. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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