Aplodan
Based on 1 Customer Validation
Aplodan (Creatinol O-phosphate) is an antiischemic and antiarrhythmic agent. Aplodan has a protective action on cell membrane. Aplodan has the potential for the research of ischemic heart or acute myocardial infarction .
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.20%
- CAS 番号: 6903-79-3
- 分子式: C4H12N3O4P
- 分子量:197.13
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Aplodan (1-10 mM; 30 min) can decrease Phosphocreatine and ATP signals in isolated heart of Xenopus Africanus and affect cardiometabolic metabolism in the 31P NMR spectroscopy study[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 6903-79-3
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性状 Solid
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分子量 197.13
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分子式 C4H12N3O4P
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Color White to off-white
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SMILES
N=C(N)N(C)CCOP(O)(O)=O
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別名
Creatinol O-phosphate; Creatinol phosphate; Creatinolfosfate; クレアチノールホスファート
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
H2O : 62.5 mg/mL (317.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Olsen JI, et al. A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain. Pharmacol Res. 1993 Sep;28(2):135-51. [Content Brief]
[2]. Botti G, et al. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects. Arzneimittelforschung. 1979;29(9a):1491-1494. [Content Brief]
[3]. Di Maio F, et al. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial. Arzneimittelforschung. 1979;29(9a):1488-1490. [Content Brief]
[4]. Knippel M, et al. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction. Arzneimittelforschung. 1979;29(9a):1480-2. [Content Brief]
[5]. Godfraind T, et al. An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat. Arzneimittelforschung. 1979;29(9a):1457-64. [Content Brief]
[6]. Marchetti G, et al. Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs. Arzneimittelforschung. 1978;28(10):1708-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0728 mL | 25.3640 mL | 50.7279 mL | 126.8199 mL |
| 5 mM | 1.0146 mL | 5.0728 mL | 10.1456 mL | 25.3640 mL | |
| 10 mM | 0.5073 mL | 2.5364 mL | 5.0728 mL | 12.6820 mL | |
| 15 mM | 0.3382 mL | 1.6909 mL | 3.3819 mL | 8.4547 mL | |
| 20 mM | 0.2536 mL | 1.2682 mL | 2.5364 mL | 6.3410 mL | |
| 25 mM | 0.2029 mL | 1.0146 mL | 2.0291 mL | 5.0728 mL | |
| 30 mM | 0.1691 mL | 0.8455 mL | 1.6909 mL | 4.2273 mL | |
| 40 mM | 0.1268 mL | 0.6341 mL | 1.2682 mL | 3.1705 mL | |
| 50 mM | 0.1015 mL | 0.5073 mL | 1.0146 mL | 2.5364 mL | |
| 60 mM | 0.0845 mL | 0.4227 mL | 0.8455 mL | 2.1137 mL | |
| 80 mM | 0.0634 mL | 0.3170 mL | 0.6341 mL | 1.5852 mL | |
| 100 mM | 0.0507 mL | 0.2536 mL | 0.5073 mL | 1.2682 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Aplodan 関連分類
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