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製品番号: HY-164107

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Auristatin S

Auristatin S is a potent Auristatin payload. Auristatin S binds to the vinca-binding site on tubulin, thereby inhibiting microtubule assembly and inducing cell cycle arrest and apoptosis. Auristatin S acts as a cytotoxic component of antibody-drug conjugates (ADCs) and exerts target-specific cytotoxicity against cancer cells. Auristatin S can be used in the research of lymphoma, anaplastic large cell lymphoma and Hodgkin lymphoma.

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CAS 番号: 3028453-70-2
分子式: C₃₈H₆₅N₅O₈
分子量:719.95

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Auristatin S 構造式

CAS 番号: 3028453-70-2

価格（税別）

Amount: USD 0.00

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

生物活性

製品説明

ADC Payloads アイソフォーム固有の製品をすべて表示 :

体外実験

Auristatin S (1.4 μM; 1 h) competes with FITC-MMAE for binding to tubulin in a cell-free system^[1].
Auristatin S has a LogD value of 1.6, exhibiting lower hydrophobicity and cell permeability compared with MMAE^[1].
Auristatin S (96 h) exerts in vitro cytotoxic effects in lymphoma cell lines (DEL, Karpas299, KarpasBVR, L540cy, etc.), with a mean IC₅₀ value of 20 nM^[1].
Auristatin S (100 nM; 18-72 h) induces markers of immunogenic cell death (HMGB1 release and ATP release) in MiaPaCa and L540cy cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 3028453-70-2
分子量 719.95
分子式 C₃₈H₆₅N₅O₈
SMILES

CC[C@@H]([C@H](N(C([C@H](C(C)C)NC([C@H](CO)N(C)C)=O)=O)C)[C@H](OC)CC(N1CCC[C@H]1[C@@H]([C@@H](C)C(N[C@@H](CC2=CC=CC=C2)CO)=O)OC)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Moquist PN, et al. Auristatin S: An Auristatin Payload with Improved Tolerability and Modified Bystander Activity. ACS medicinal chemistry letters. 2025 Jul 10;16(7):1354-1358. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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