Avenanthramide B
Based on 1 publication(s) in Google Scholar
Avenanthramide B is an oat phytoalexin, a porcine liver esterase inhibitor, and an amyloglucosidase inhibitor, with an IC50 of 4.4 mg/mL against Aspergillus niger amyloglucosidase. Avenanthramide B increases the activation status of Akt1 and the expression level of eNOS, elevates the levels of NO and cGMP, and reduces the level of superoxide anions. Avenanthramide B acts on amyloglucosidase via a competitive mixed mechanism, functions as a fluorescence quencher, and exerts bidirectional regulatory effects on protein thermal stability. Avenanthramide B serves as a substrate for oat leaf peroxidase. Avenanthramide B can be used in research related to type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 108605-69-2
- 分子式: C17H15NO6
- 分子量:329.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Avenanthramide B
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生物活性
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Akt1 |
Avenanthramide B (1 µM; 24 h) significantly increases intracellular NO levels and cGMP production, reduces superoxide anion generation, enhances Akt1 activation, and upregulates the protein expression level of eNOS in HUVEC cells[2].
Avenanthramide B (50 µM; 10 min) significantly inhibits the activity of porcine liver esterase[1].
Avenanthramide B (31.3-1000 μg/mL) inhibits amyloglucosidase derived from Aspergillus niger via a competitive-dominant mixed-type mechanism, with an IC50 value of 4.4 mg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC
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Concentration:1 µM
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Incubation Time:24 h
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Result:Significantly increased cGMP levels compared to vehicle control.
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Cell Line:HUVEC
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Concentration:1 µM
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Incubation Time:2 h
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Result:Significantly increased the Akt1 phosphorylation/total protein ratio compared to vehicle control, indicating enhanced Akt1 activation.
Significantly increased eNOS protein expression compared to vehicle control.
化学情報
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CAS 番号 108605-69-2
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性状 Solid
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分子量 329.31
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分子式 C17H15NO6
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SMILES
C(O)(=O)C1=C(NC(/C=C/C2=CC(OC)=C(O)C=C2)=O)C=CC(O)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
[1]. Lim H, et al. Compared Inhibitory Activities of Tamoxifen and Avenanthramide B on Liver Esterase and Correlation Based on the Superimposed Structure Between Porcine and Human Liver Esterase. International journal of molecular sciences. 2024 Dec 11;25(24):13291. [Content Brief]
[2]. Serreli G, et al. Ferulic Acid Derivatives and Avenanthramides Modulate Endothelial Function through Maintenance of Nitric Oxide Balance in HUVEC Cells. Nutrients. 2021 Jun 12;13(6):2026. [Content Brief]
[3]. Feng W, et al. Unraveling the inhibition mechanism of avenanthramides on amyloglucosidase: Probing by multi-spectroscopic techniques, enzyme kinetics, and molecular docking simulations. Food chemistry. 2026 Apr 30;509:148552. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Avenanthramide B 関連分類
HY-W795967 関連分類
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