AZD9898
Based on 1 publication(s) in Google Scholar
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 2042347-69-1
- 分子式: C20H19ClF3N3O4
- 分子量:457.83
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 AZD9898
More
生物活性
IC50: 0.28 nM (LTC4S)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rat 6M/group[1].
-
Dosage:10 and 100 mg/kg (for Toxicology Study).
-
Administration:Sing oral dose.
-
Result:Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 2042347-69-1
-
性状 Solid
-
分子量 457.83
-
分子式 C20H19ClF3N3O4
-
Color Light yellow to yellow
-
SMILES
O=C([C@@H]1[C@@H](C(C2=NC=C(N(C3=CC(Cl)=C(F)C=C3F)CC(C)(F)C)N=C2OC)=O)C1)O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung. [Abstract]2026 Jan 22;17(1):1946. PMID: 41571657
溶剤 & 溶解度
DMSO : ≥ 250 mg/mL (546.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (277 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1842 mL | 10.9211 mL | 21.8422 mL | 54.6054 mL |
| 5 mM | 0.4368 mL | 2.1842 mL | 4.3684 mL | 10.9211 mL | |
| 10 mM | 0.2184 mL | 1.0921 mL | 2.1842 mL | 5.4605 mL | |
| 15 mM | 0.1456 mL | 0.7281 mL | 1.4561 mL | 3.6404 mL | |
| 20 mM | 0.1092 mL | 0.5461 mL | 1.0921 mL | 2.7303 mL | |
| 25 mM | 0.0874 mL | 0.4368 mL | 0.8737 mL | 2.1842 mL | |
| 30 mM | 0.0728 mL | 0.3640 mL | 0.7281 mL | 1.8202 mL | |
| 40 mM | 0.0546 mL | 0.2730 mL | 0.5461 mL | 1.3651 mL | |
| 50 mM | 0.0437 mL | 0.2184 mL | 0.4368 mL | 1.0921 mL | |
| 60 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9101 mL | |
| 80 mM | 0.0273 mL | 0.1365 mL | 0.2730 mL | 0.6826 mL | |
| 100 mM | 0.0218 mL | 0.1092 mL | 0.2184 mL | 0.5461 mL |
AZD9898 関連分類
HY-126329 関連分類
Powered by Bioz