BBMP
BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research.
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- CAS 番号: 97120-13-3
- 分子式: C12H11BrN2O3S
- 分子量:343.20
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BBMP is effective in both swelling and membrane potential assays displaying pIC50 values of 5.5 and 5.6, respectively. BBMP dose-dependently prevents DNA fragmentation induced by KCl 25/5 mM shift and serum deprivation in cerebellar granule neurons with a pIC50 of 5.7. The inhibition of PTP-mediated cytochrome c release observed in isolated mitochondria at 10 and 100 μM may explain its neuroprotective properties in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 97120-13-3
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分子量 343.20
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分子式 C12H11BrN2O3S
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SMILES
O=C1C(Br)=C(S(=O)(CC2=CC=CC=C2)=O)C=NN1C
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別名
5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BBMP 関連分類
HY-108984 関連分類
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