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製品番号: HY-103279

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BIM187

BIM187 is a Bombesin Receptor agonist that induces satiety. BIM187 significantly reduces short-term food intake in rats, but does not alter the total 6 h food intake of rats. BIM187 can be used in studies related to feeding behavior and satiety regulation in rats.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 137734-88-4
分子式: C₅₃H₇₆N₁₄O₁₀
分子量:1069.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BIM187 構造式

CAS 番号: 137734-88-4

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

BIM187 (0.5-32 μg/kg; i.p.; single dose) induces significant satiety in rats by reducing 30-minute food intake at doses of 4 μg/kg and above, with no effect on total 6-hour food intake, and this satiety effect is independent of CCK-mediated pathways and not antagonized by BIM189 at 20 μg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, starting weight 150-170 g, experimental weight 190-210 g, maintained on 6-hour daily food access, fasted 18 hours prior to experiments)^[1]
Dosage:

0.5 μg/kg; 1 μg/kg; 2 μg/kg; 4 μg/kg; 8 μg/kg; 16 μg/kg; 32 μg/kg
Administration:

i.p.; single dose
Result:

Exerted no meaningful 30-min feeding suppression at 0.5, 1, 2 μg/kg.
Markedly cut 30-min food intake at 4, 8, 16, 32 μg/kg with non-dose-dependent activity.
Suppressed 30-min feeding significantly at 4 μg/kg and left total 6-h intake unchanged versus control.
Lowered 30-min food intake at 32 μg/kg, reduced 60-min intake, with intact total 6-h feeding volume.
Retained full 30-min feeding suppression after co-administration with CCK antagonists BIM18216 (1 mg/kg) and Devazepide (HY-106301) (100 μg/kg).
Maintained unaltered 30-min anorectic action against bombesin antagonist BIM189 (20 μg/kg) at 4 μg/kg.

化学情報

CAS 番号 137734-88-4
分子量 1069.28
分子式 C₅₃H₇₆N₁₄O₁₀
SMILES

C([C@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)N)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)C(C)C)=O)C)=O)C=3C=4C(NC3)=CC=CC4
配列

{d-Phe}-Gln-Trp-Ala-Val-Gly-His-Leu-Leu-NH2
シーケンスの短縮

{d-Phe}-QWAVGHLL-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Laferrère B, et al. Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. European journal of pharmacology. 1992 Apr 29;215(1):23-8. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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