BMS-869780
BMS-869780 is an orally active non-acidic γ-secretase (γ-secretase) modulator. BMS-869780 regulates the activity of γ-secretase, thereby altering the production profile of β-amyloid proteins. When acting alone, it changes the relative levels of specific β-amyloid subtypes without inhibiting the total production of β-amyloid proteins. BMS-869780 exerts a synergistic effect with γ-secretase modulators of the acidic structural class to inhibit the total production of β-amyloid proteins in cell cultures.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1235493-78-3
- 分子式: C23H22ClFN6O
- 分子量:452.92
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
BMS-869780 alone does not inhibit the production of total Aβ, but when combined with acidic GSMs (GSM-2 or GSM-1 (HY-119165)) in human glioma H4-APPsw cells, it exhibits strong synergistic inhibitory effects on the production of Aβ1-x and Aβ1-40 (with combination index values as low as 0.05-0.06), and can induce the accumulation of α-CTF[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 (12-week-old male/female, wild-type)[1]
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Dosage:25 mg/kg
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Administration:p.o.; single dose
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Result:Significantly decreased brain Aβ1-42 levels relative to vehicle controls at 3 hours post-dose.
Showed no significant change in brain Aβ1-x levels relative to vehicle controls at 3 hours post-dose.
Remained significantly decreased brain Aβ1-42 levels relative to vehicle controls at 6 hours post-dose.
Showed no significant change in brain Aβ1-x levels relative to vehicle controls at 6 hours post-dose.
Produced no significant synergistic reduction in brain Aβ1-x levels when administered in combination with GSM-2 at 3 or 6 hours post-dose.
Showed a small significant reduction in Aβ1-42 levels at 6 hours post-dose relative to BMS-869780 alone when administered in combination with GSM-2.
化学情報
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CAS 番号 1235493-78-3
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分子量 452.92
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分子式 C23H22ClFN6O
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SMILES
N(C=1N=C2[C@@H](CCCCN2N1)C3=CC=C(F)C=C3)C4=CC(OC)=C(C=C4)N5C=NC(Cl)=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMS-869780 関連分類
HY-18326 関連分類
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