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製品番号: HY-N19744

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(-)-Calanolide B

(-)-Calanolide B is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC₅₀ of 0.5 mM against HIV-1 RT. (-)-Calanolide B inhibits the replication of HIV-1 IIIb/LAV. (-)-Calanolide B is applicable to research related to HIV-1 infection.

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CAS 番号: 909-14-8
分子式: C₂₂H₂₆O₅
分子量:370.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Calanolide B 構造式

CAS 番号: 909-14-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

HIV-1 RT

0.5 mM (IC₅₀)

HIV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	18.7 μM Compound: (-)-1	Anti-HIV activity against HIV-I RFII strain in CEM cell line Anti-HIV activity against HIV-I RFII strain in CEM cell line	[PMID: 8632437]
CEM-SS	EC₅₀	0.2 μM Compound: 2	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	5.9 μM Compound: 2	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	0.2 μM Compound: (-)-Calanolide B	Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 11430019]
H9	EC₅₀	0.22 μM Compound: 13	Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay	[PMID: 8792623]
H9	IC₅₀	9.8 μM Compound: 13	Cytotoxicity against human H9 cells Cytotoxicity against human H9 cells	[PMID: 8792623]
MT2	IC₅₀	5.89 μM Compound: (-)-1	Anti-HIV activity against HIV-I A17 strain in MT2 cell line Anti-HIV activity against HIV-I A17 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.16 μM Compound: (-)-1	Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.21 μM Compound: (-)-1	Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	7.31 μM Compound: (-)-1	Anti-HIV activity against HIV-I IIIB strain in MT2 cell line Anti-HIV activity against HIV-I IIIB strain in MT2 cell line	[PMID: 8632437]

体外実験

(-)-Calanolide B (Compound 7) at 1 mM potently inhibits HIV-1 RT, with an IC₅₀ of 0.5 mM and an inhibition rate of 76.2% at 1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 909-14-8
分子量 370.44
分子式 C₂₂H₂₆O₅
SMILES

CCCC(C1=C(O2)C3=C(O[C@H]([C@@H]([C@@H]3O)C)C)C4=C1OC(C)(C=C4)C)=CC2=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Huerta-Reyes M, Basualdo Mdel C, Abe F, et al.. HIV-1 inhibitory compounds from Calophyllum brasiliense leaves. Biological & pharmaceutical bulletin. 2004 Sep;27(9):1471-5. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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