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United States

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製品番号: HY-182628

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CJ-036878

CJ-036878 is a NMDAR NR2B subunit antagonist. CJ-036878 is applicable to research related to persistent inflammatory pain and neuropathic pain.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 951248-25-2
分子式: C₂₂H₂₁NO₃
分子量:347.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CJ-036878 構造式

CAS 番号: 951248-25-2

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CJ-036878 is a NMDAR NR2B subunit antagonist. CJ-036878 is applicable to research related to persistent inflammatory pain and neuropathic pain^[1]^[2].

IC₅₀ & Target

^[1]

NR2B

iGluR アイソフォーム固有の製品をすべて表示 :

体外実験

CJ-036878 is a NMDAR NR2B subunit antagonist, is applicable to research related to persistent inflammatory pain and neuropathic pain^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 951248-25-2
分子量 347.41
分子式 C₂₂H₂₁NO₃
SMILES

O=C(C1=CC=C(C=C1)O)NCC2=CC(OCCC3=CC=CC=C3)=CC=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Animals and Diseases

Formalin-Induced Paw Inflammation/Nociceptive Inflammation
The formalin-induced paw inflammation/nociceptive test is a chemical persistent pain model in rodents in which subcutaneous injection of formalin into the hind paw produces spontaneous nocifensive behaviors such as flinching and licking. The response is classically biphasic, consisting of an early acute phase (Phase I) reflecting direct activation of peripheral nociceptors (particularly C-fiber afferents), followed by a later prolonged phase (Phase II) associated with central sensitization in the spinal dorsal horn driven by sustained afferent input and inflammatory signaling. This model is widely used to evaluate analgesic and anti-inflammatory interventions because it captures both peripheral nociception and central sensitization processes within a single assay system.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Emoto C, et al. CYP3A4 and CYP3A5 catalyse the conversion of the N-methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers. Xenobiotica. 2007;37(12):1408-1420. [Content Brief]

[2]. Nishida H, et al. Metabolism of CJ-036878, N-(3-phenethoxybenzyl)-4-hydroxybenzamide, in liver microsomes and recombinant cytochrome P450 enzymes: metabolite identification by LC-UV/MS(n) and (1)H-NMR. Xenobiotica. 2007 Dec;37(12):1394-407. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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