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製品番号: HY-P11709

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CLPVASC

Name: CLPVASC
Brand: MedChemExpress
SKU: HY-P11709
Availability: PreOrder

(別名: cyclo(CLPVASC))

CLPVASC is a kidney-targeting cyclic peptide that preferentially distributes to kidney tissue, with utility to enhance kidney targeting of nanocarriers.CLPVASC preferentially distributes to the kidney when displayed on PEG-b-PPS micelles. CLPVASC can be used for the research of acute kidney injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3106628-26-3
分子式: C₂₈H₄₇N₇O₉S₂
分子量:689.84

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLPVASC 構造式

CAS 番号: 3106628-26-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Micelles co-displaying CLPVASC (1% molar ratio) and CYNTTTHRC (1% molar ratio) (17 mg/mL MC; i.v. (retro-orbital route); single dose) show a 3.4-fold higher uptake in the kidneys of mice with ischemia-reperfusion injury than in the contralateral control kidneys, with reduced off-target distribution to other organs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (female, 17.5 to 22.5 weeks old, unilateral renal ischemia-reperfusion injury)^[1]
Dosage:

MC loaded with 0.3% w/w DiI, displaying CLPVASC at a 1% molar ratio alongside CYNTTTHRC at a 1% molar ratio, at an overall MC concentration of 17 mg/mL
Administration:

i.v. (retro-orbital route); single dose
Result:

Achieved 3.4-fold higher uptake in the ischemia-reperfusion injured kidney compared to the contralateral control kidney.
Showed 2.3-fold higher uptake in the injured kidney than in the lungs.
Exhibited 67% higher uptake in the injured kidney than that of non-targeted MC.

Related Protocols :

Nephrotoxicity Study

化学情報

CAS 番号 3106628-26-3
分子量 689.84
分子式 C₂₈H₄₇N₇O₉S₂
別名

cyclo(CLPVASC)
配列

cyclo(Cys-Leu-Pro-Val-Ala-Ser-Cys)
シーケンスの短縮

cyclo(CLPVASC)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bishop BY, et al. Enabling organ- and injury-specific nanocarrier targeting via surface-functionalized PEG-b-PPS micelles for acute kidney injury. Nanoscale Horiz. 2025 Nov 17;10(12):3423-3432. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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