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製品番号: HY-158003

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COE-PNH2

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC₉₀ of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₅₄H₉₈Cl₈N₈O₄
分子量:1207.03

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

COE-PNH2 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

COE-PNH2 (0-128 μg/mL) exhibits a stable antibacterial activity and extreme antibiotic tolerance against intracellular, replicating and nutrient-starved, non-replicating Mab^[1].
COE-PNH2 exhibits a low propensity for resistance development with consistent MIC values in 14 passages of Mab^[1].
COE-PNH2 (0-64 μg/mL) induces a depletion of ATP, accumulation of intracellular lipid inclusions (ILIs) and bacterial elongation in Mab^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

COE-PNH2 (2.5-5 mg/kg, intratracheal, every other day for 12 days) exhibits well tolerance and efficiency in acute lung infection in C3HeB/FeJ mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Acute lung infection in C3HeB/FeJ mice^[1]
Dosage:

2.5-5 mg/kg
Administration:

Intratracheal administration every other day for 12 days
Result:

Reduced the colony-forming units (CFU) and bacilli in lung without weight loss.

化学情報

分子量 1207.03
分子式 C₅₄H₉₈Cl₈N₈O₄
SMILES

C[N+](C)(CCCN)CCCOC1=CC(/C=C/C2=CC=C(/C=C/C3=CC(OCCC[N+](C)(CCCN)C)=CC(OCCC[N+](C)(CCCN)C)=C3)C=C2)=CC(OCCC[N+](C)(CCCN)C)=C1.[Cl-].[Cl-].[Cl-].[Cl-].Cl.Cl.Cl.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang K, et al., An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus. Sci Transl Med. 2024 Feb 21;16(735):eadi7558. [Content Brief]

Calculators

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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