Coramitug
Based on 1 Customer Validation
Coramitug (PRX004) is a human IgG1 κ monoclonal antibody against TTR. Coramitug binds to a specific epitope on misfolded/aggregated TTR and promotes antibody-mediated clearance. Coramitug can be used in research on transthyretin amyloidosis with cardiomyopathy (ATTR-CM) and variant transthyretin (ATTRv) amyloidosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.00%
- CAS 番号: 2626841-92-5
- 分子量:147.749 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
|
Transthyretin/TTR |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1X106 A549 cells labeling TTR with Coramitug (HY-P990734, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
化学情報
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CAS 番号 2626841-92-5
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性状 Liquid
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分子量 147.749 kDa
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Color Colorless to light yellow
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別名
PRX004; NNC6019-0001
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Keywords
- Coramitug
- 2626841-92-5
- PRX004
- NNC6019-0001
- PRX 004
- PRX-004
- Transthyretin (TTR)
- TTR amyloid deposits
- amyloid fibril formation
- antibody-dependent phagocytosis
- misfolded transthyretin
- native tetrameric transthyretin
- opsonisation
- transthyretin
- transthyretin amyloidosis with cardiomyopathy
- variant amyloid transthyretin amyloidosis
- Inhibitor
- inhibitor
- inhibit