CPPD-Q
Based on 1 publication(s) in Google Scholar
CPPD-Q is a PPD-quinone. CPPD-Q induces increased intestinal permeability and oxidative stress in C. elegans. CPPD-Q targets HMP-2 and ACS-22 to regulate the intestinal barrier, and targets SOD-3 and GST-4 to mediate oxidative stress responses. CPPD-Q induces reactive oxygen species (ROS) production through quinone-mediated redox cycling, and exhibits oxidative potential through dithiothreitol depletion. CPPD-Q is used in research related to intestinal diseases.
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- 純度 : 99.12%
- CAS 番号: 68054-78-4
- 分子式: C18H20N2O2
- 分子量:296.36
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
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- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 CPPD-Q
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生物活性
製品説明
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HMP-2 |
ACS-22 |
SOD-3 |
GST-4 |
体外実験
CPPD-Q (10-100 μM; 30 min) as part of a six-chemical mixture increases HK-2 ROS release to 118-241 % of control[3].
CPPD-Q (20 μM; 24 h) as part of a six-chemical mixture dysregulates oxidative stress genes in HK-2 cells, upregulating CCL5, SLC7A11, FTH1, SPINK1, FHL2, PRNP, CYBB, NCF2, TXNRD1, and GCLM and downregulating MB[3].
CPPD-Q (10-100 μM; 24 h) as part of a six-chemical mixture reduces HK-2 cell viability from 92.4 % to 61.2 %, indicating cytotoxicity[3].
CPPD-Q (0.01-20 mg/L; 30 min) inhibits Vibrio fischeri bioluminescence with a 30-min EC50 of 6.98 mg/L (extrapolated), indicating toxic acute aquatic toxicity[5].
CPPD-Q (0.01-0.19 μM; 0-36 min) exhibits a DTT consumption rate of 1.17 μM min−1 μM−1 in the cell-free DTT assay, indicating intrinsic oxidative potential[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human Kidney-2 (HK-2) cells
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Concentration:0, 10, 20, 40, 80, 100 μM (per individual chemical)
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Incubation Time:24 h
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Result:Cell viability of HK-2 cells decreased from 92.4 % to 61.2 % after 24-h exposure to the six-chemical mixture containing CPPD-Q.
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Cell Line:Human Kidney-2 (HK-2) cells
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Concentration:0 and 20 μM (per individual chemical)
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Incubation Time:24 h
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Result:After 24-h exposure to the six-chemical mixture containing CPPD-Q at 20 μM, ten of 90 genes were significantly upregulated: CCL5, SLC7A11, FTH1, SPINK1, FHL2, PRNP, CYBB, NCF2, TXNRD1, and GCLM.
One gene, MB, was significantly downregulated.
体内実験
CPPD-Q (0.01‑10 μg/L; solution exposure; from L1 larvae exposure to day 1 of adulthood) activates the GST‑4 detoxification and SOD‑3‑mediated antioxidant defense pathways in nematodes[1].
Under CPPD-Q exposure conditions (0.01‑10 μg/L; solution exposure; from L1 larvae to day 1 of adulthood), loss of hmp‑2 and pkc‑3 function amplifies CPPDQ-induced intestinal oxidative damage; knockdown of acs‑22 and erm‑1 does not exacerbate CPPDQ-induced ROS[1].
CPPD-Q (0.01-10 μg/L; solution exposure; from L1 larvae exposure to day 1 of adulthood) disrupts nematode intestinal barrier function in a concentration-dependent manner; at high concentration (10 μg/L), the damage is more severe, with complete barrier leakage[1].
CPPD-Q (0.01‑10 μg/L; solution exposure; from L1 larvae exposure to day 1 of adulthood) primarily mediates impairment of the intestinal barrier function in C. elegans by inhibiting the expression of hmp‑2 and acs‑22 genes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type N2 Caenorhabditis elegans
[1] -
Dosage:0.01 μg/L; 0.1 μg/L; 1 μg/L; 10 μg/L
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Administration:solution exposure; from L1 larvae to day 1 of adulthood
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Result:Disrupted the intestinal barrier function of the nematode.
Inhibited the expression of the hmp-2 and acs-22 genes.
Induced oxidative stress in the nematode intestine.
Activated the C. elegans GST-4 detoxification and SOD-3-mediated antioxidant defense pathways.
化学情報
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CAS 番号 68054-78-4
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性状 Solid
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分子量 296.36
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分子式 C18H20N2O2
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Color Brown to red
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SMILES
O=C1C(NC2CCCCC2)=CC(C(NC3=CC=CC=C3)=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Environ Pollut
2026 Jul 1:400:128295. PMID: 42105897
溶剤 & 溶解度
体外:
DMSO : 1 mg/mL (3.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. Wang Y, et al. Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans. The Science of the total environment. 2024 Jun 01;927:172306. [Content Brief]
[5]. Wang W, et al. Toxicity of substituted p-phenylenediamine antioxidants and their derived novel quinones on aquatic bacterium: Acute effects and mechanistic insights. Journal of hazardous materials. 2024 May 05;469:133900. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3743 mL | 16.8714 mL | 33.7427 mL | 84.3569 mL |
CPPD-Q 関連分類
HY-W728085 関連分類
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