Cycloposine
Based on 1 Customer Validation
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound that may induce cyclopia in pregnant Mianyang embryos.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 23185-94-6
- 分子式: C33H51NO7
- 分子量:573.76
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Cycloposine producs fetal cyclopia and related central nervous system malformations in sheep[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 23185-94-6
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性状 Solid
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分子量 573.76
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分子式 C33H51NO7
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Color White to off-white
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SMILES
CC1=C(C[C@@]2([H])[C@@]3([H])CC=C4[C@@]2(CC[C@@H](C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)[C@@]3([H])CC[C@]16O[C@@]7([H])[C@](NC[C@H](C7)C)([H])[C@H]6C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 46.67 mg/mL (81.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (643 KB)
- English - EN (643 KB)
- Français - FR (643 KB)
- Deutsch - DE (643 KB)
- Norwegian - NO (643 KB)
- Español - ES (643 KB)
- Swedish - SV (643 KB)
- Italian - IT (643 KB)
- Korean - KR (643 KB)
- Portuguese - PT (643 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Chandler CM, et, al. Improved extraction and complete mass spectral characterization of steroidal alkaloids from Veratrum californicum. Nat Prod Commun. 2013 Aug;8(8):1059-64. [Content Brief]
[2]. Keeler RF. Teratogenic compounds of Veratrum californicum (Durand). VII. The structure of the glycosidic alkaloid cycloposine. Steroids. 1969 May;13(5):579-88. [Content Brief]
[3]. Heretsch P, et al. Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives. Angew Chem Int Ed Engl. 2010 May 3;49(20):3418-27. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7429 mL | 8.7144 mL | 17.4289 mL | 43.5722 mL |
| 5 mM | 0.3486 mL | 1.7429 mL | 3.4858 mL | 8.7144 mL | |
| 10 mM | 0.1743 mL | 0.8714 mL | 1.7429 mL | 4.3572 mL | |
| 15 mM | 0.1162 mL | 0.5810 mL | 1.1619 mL | 2.9048 mL | |
| 20 mM | 0.0871 mL | 0.4357 mL | 0.8714 mL | 2.1786 mL | |
| 25 mM | 0.0697 mL | 0.3486 mL | 0.6972 mL | 1.7429 mL | |
| 30 mM | 0.0581 mL | 0.2905 mL | 0.5810 mL | 1.4524 mL | |
| 40 mM | 0.0436 mL | 0.2179 mL | 0.4357 mL | 1.0893 mL | |
| 50 mM | 0.0349 mL | 0.1743 mL | 0.3486 mL | 0.8714 mL | |
| 60 mM | 0.0290 mL | 0.1452 mL | 0.2905 mL | 0.7262 mL | |
| 80 mM | 0.0218 mL | 0.1089 mL | 0.2179 mL | 0.5447 mL |
Cycloposine 関連分類
HY-128683 関連分類
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