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製品番号: HY-187763

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Dircin

Dircin is a daphnane-type diterpene ester natural product found in the branches and flowers of Dirca occidentalis A. Gray. It exhibits potent cytotoxicity against P-388 lymphocytic leukemia cells, with a ED₅₀ of 0.00000025 μg/mL. Dircin can be used in studies of leukemia and plant-derived cytotoxic daphnane-type diterpene esters.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 88497-93-2
分子式: C₃₉H₅₂O₁₁
分子量:696.83

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dircin 構造式

CAS 番号: 88497-93-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Anti-cancer

Dircin (compound II) potently inhibits P-388 lymphocytic leukemia cells in vitro, with an ED₅₀ of 0.00000025 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Anti-cancer

Dircin (compound II) (125 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a T/C value of 156% for survival time^[1].
Dircin (62.5 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a survival time T/C value of 147%^[1].
Dircin (31.3 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a survival time T/C value of 125%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six CD2F1 male P-388 tumor-bearing mice^[1]
Dosage:

125 μg/kg
Administration:

Intraperitoneal administration over a 10-day period
Result:

Produced a survival T/C value of 156%.

Animal Model:

Six CD2F1 male P-388 tumor-bearing mice^[1]
Dosage:

62.5 μg/kg
Administration:

Intraperitoneal administration over a 10-day period
Result:

Produced a survival T/C value of 147%.

Animal Model:

Six CD2F1 male P-388 tumor-bearing mice^[1]
Dosage:

31.3 μg/kg
Administration:

Intraperitoneal administration over a 10-day period
Result:

Produced a survival T/C value of 125%.

Related Protocols :

化学情報

CAS 番号 88497-93-2
分子量 696.83
分子式 C₃₉H₅₂O₁₁
SMILES

C[C@H]1[C@@]23[C@]4([C@]5([C@](CO)(O5)[C@@H](O)[C@@]6(O)[C@]2([C@]([C@H](C)[C@@H]6OC(=O)C7=CC=CC=C7)([C@@H](C)CCCCCC[C@@H](OC(C)=O)[C@@]8(O3)O[C@]4([C@](C(C)=C)(C1)O8)[H])[H])[H])[H])[H]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Badawi MM, et al. Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae). Journal of pharmaceutical sciences. 1983 Nov;72(11):1285-7. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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