Divin
Based on 1 Customer Validation
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.65%
- CAS 番号: 1443321-11-6
- 分子式: C22H20N4O2
- 分子量:372.42
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 1443321-11-6
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性状 Solid
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分子量 372.42
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分子式 C22H20N4O2
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Color Light yellow to brown
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SMILES
O=C(N/N=C/C1=C2C=CC=CC2=CC=C1O)CCN3C4=CC=CC=C4N=C3C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 20 mg/mL (53.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Maoquan Zhou, et al. Structure-activity studies of divin: an inhibitor of bacterial cell division. ACS Med Chem Lett. 2013 Sep 12;4(9):880-885. [Content Brief]
[2]. Ye-Jin Eun, et al. Divin: a small molecule inhibitor of bacterial divisome assembly. J Am Chem Soc. 2013 Jul 3;135(26):9768-76. [Content Brief]
[3]. Thiago M A Santos, et al. Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis. ACS Chem Biol. 2018 Jan 19;13(1):235-246. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6851 mL | 13.4257 mL | 26.8514 mL | 67.1285 mL |
| 5 mM | 0.5370 mL | 2.6851 mL | 5.3703 mL | 13.4257 mL | |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
| 15 mM | 0.1790 mL | 0.8950 mL | 1.7901 mL | 4.4752 mL | |
| 20 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 25 mM | 0.1074 mL | 0.5370 mL | 1.0741 mL | 2.6851 mL | |
| 30 mM | 0.0895 mL | 0.4475 mL | 0.8950 mL | 2.2376 mL | |
| 40 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6782 mL | |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3426 mL |
Divin 関連分類
HY-124712 関連分類
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