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DNMT1-IN-5

DNMT1-IN-5 (Compound 55) is the inhibitor for DNMT that inhibits DNMT1 and DNMT3A with IC50 of 2.42 μM and 14.4 μM. DNMT1-IN-5 exhibits antiproliferative activity in a variety of cancer cell lines (IC50s for TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226 and HCT116 are 0.19-2.37 μM), arrests the cell cycle at G2/M phase, and induces apoptosis in TMD-8 and DOHH2 cells. DNMT1-IN-5 exhibits antitumor efficacy in TMD-8 xenograft mouse models.

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  • CAS 番号: 2982511-19-1
  • 分子式: C24H32FN7
  • 分子量:437.56
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • DNMT1-IN-5 Chemical Structure
    DNMT1-IN-5 構造式
CAS 番号: 2982511-19-1
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  • DNMT1-IN-5 Chemical Structure
    DNMT1-IN-5 Chemical Structure
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  • DNMT1-IN-5