country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187478A

Copy Link Print Information

DOPE-PEG2000-EB1

(別名: DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK)

DOPE-PEG2000-EB1 (DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the EB1 peptide (a penetratin analog). EB1 peptide is an endosomolytic agent that forms an amphipathic alpha helix upon protonation in endosomes, driving endosomal membrane permeabilization. DOPE-PEG2000-EB1 is used for intracellular delivery of nucleic acids (e.g., siRNA) and other macromolecular therapeutics.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-EB1 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

DOPE-PEG2000-EB1: functionalization of liposomes and nanoparticles for enhanced intracellular delivery of siRNA, nucleic acids, and macromolecular drugs, particularly to overcome the endosomal escape barrier.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes membrane destabilization and fusion under acidic conditions;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization, and extends circulation time;
(3) EB1 peptide; a penetratin analog and endosomolytic agent that forms an amphipathic alpha helix upon protonation in early-to-late endosomes, permeabilizing endosomal membranes and enabling encapsulated cargo (e.g., siRNA) to escape into the cytosol for effective gene silencing.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

SMILES

[DOPE-PEG2000-EB1]
別名

DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.