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製品番号: HY-177779

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dRRM-1

dRRM-1 is a DCAF15-dependent RBM39/RBM23 molecular glue degrader. dRRM-1 stabilizes the interaction between DCAF15 and the novel substrates RBM39 and RBM23, thereby triggering their ubiquitination and degradation. dRRM-1 can be applied in research related to cancer.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 253328-68-6
分子式: C₁₆H₁₄N₂O₂S
分子量:298.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

dRRM-1 構造式

CAS 番号: 253328-68-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

RBM39

RBM23

体外実験

dRRM-1 (3 days) exerts cytotoxic effects that reduce cell viability to varying degrees in KBM7, MV4;11, RS4;11, HCT116, and HEK293T cells^[1].
dRRM-1 (5-20 µM; 10 h) exhibits the effect of degrading the RBM39 protein in RS4;11, KBM7, HEK293, and HCT116 cells^[1].
dRRM-1 (10 µM; 10 h) rescues DCAF15 from autodegradation and significantly stabilizes DCAF15 protein abundance, while markedly reducing the protein levels of RBM23 and RBM39 in HEK293t DCAF15^-/- cells expressing HiBit-DCAF15 and LgBit^[1].
dRRM-1 (0.001-100 μM; 60 min) binds to purified DCAF15 in a concentration-dependent manner, and displaces pre-bound E7820 with low binding affinity over the concentration range of 0.001 to 100 μM^[1].
dRRM-1 (10 μM; 2 h-22 h) induces proteasome-dependent degradation of RBM23 in HAP1 RBM23-NanoLuc knock-in cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293t DCAF15^-/^- cells reconstituted with HiBit-DCAF15
Concentration:

10 μM
Incubation Time:

10 h
Result:

Reduced RBM39 protein levels in DCAF15-reconstituted HEK293t cells.
Caused no reduction in RBM39 levels in DCAF15^-/^- cells, confirming DCAF15 dependency.

Western Blot Analysis^[1]

Cell Line:

RS4;11, KBM7, HEK293, HCT116 cells
Concentration:

5 µM, 20 µM
Incubation Time:

10 h
Result:

Effectively degraded RBM39 across multiple cellular backgrounds.

化学情報

CAS 番号 253328-68-6
分子量 298.36
分子式 C₁₆H₁₄N₂O₂S
SMILES

CC1=CC=C(C=C1)S(=O)(NC2=CC=C3N=CC=CC3=C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hanzl A, et al. E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society. 2023 Jan 18;145(2):1176-1184. [Content Brief]

[2]. Best AJ, et al. High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters. Nature communications. 2024 Jul 27;15(1):6328.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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