FAAH-IN-5
FAAH-IN-5 is a dual FAAH/MAGL inhibitor with IC50 values of 0.0105 μM and 0.284 μM, respectively. FAAH-IN-5 shows reduced PAMPA permeability. FAAH-IN-5 produces near-complete blockade of TAMRA-FP labeling of human FAAH and MAGL, and produces significant blockade in homogenates. FAAH-IN-5 can be used in research related to FAAH-mediated diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1338575-38-4
- 分子式: C21H19N3O6S
- 分子量:441.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 10.5 nM (FAAH), 283 nM (MAGL)[1]
体外実験
FAAH-IN-5 exhibits a low artificial membrane permeability of 2.6 × 10−7 cm/s in PAMPA[1].
FAAH-IN-5 irreversibly inhibits human recombinant FAAH in a rapid dilution assay; it almost completely blocks TAMRA-FP labeling of human FAAH and MAGL, and significantly blocks labeling in rat eye homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1338575-38-4
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分子量 441.46
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分子式 C21H19N3O6S
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SMILES
O=C(N1CCN(CC1)S(=O)(C2=CC=C3C=CC=CC3=C2)=O)OC4=CC=C(C=C4)[N+]([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FAAH-IN-5 関連分類
HY-146341 関連分類
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