FEACYP
FEACYP is a thioredoxin reductase (TrxR) inhibitor. FEACYP inhibits thioredoxin reductase activity, induces ROS by increasing basal cellular hydrogen peroxide production, suppresses tumor growth, exerts cytotoxicity against human cancer cells, and exhibits antiproliferative activity in human pancreatic cancer 3D spheroids. FEACYP can be used in the research of ovarian cancer, colon cancer, pancreatic cancer, and lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C27H37F3Fe2N4O5PS
- 分子量:729.33
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
体外実験
FEACYP (compound 2a) (72 h) potently inhibits the viability of 2008, HCT-15, PSN-1, and U1285 human cancer cells with IC50 values ranging from 2.6-4.3 μM, and is 6.2-fold more selective for cancer cells than noncancerous HEK293 cells[1].
FEACYP (72 h) inhibits Cisplatin (HY-17394)-resistant C13* human ovarian adenocarcinoma cells with an IC50 of 7.3 μM[1].
FEACYP (72 h) potently inhibits the viability of 3D PSN-1 human pancreatic cancer spheroids with an IC50 of 16.2 μM[1].
FEACYP (5 μM; 24 h) inhibits thioredoxin reductase activity in PSN-1 human pancreatic cancer cells by 52%, matching the inhibitory capacity of Auranofin (HY-B1123)[1].
FEACYP induces a time-dependent increase in reactive oxygen species production in PSN-1 human pancreatic cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:6-8 weeks, 24±3 g, Female C57BL/6 mice (LLC cells) [1]
-
Dosage:8 mg/kg
-
Administration:I.p.; daily for 15 days
-
Result:Reduced the average tumor growth by 88% with less body weight loss pronounced (∼12%).
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- ROS/oxidative-stress fluorescent staining
- Patient-Derived Xenograft (PDX)
- Patient-Derived Orthotopic Xenograft (PDOX)
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Cell Viability Determination by MTT Colorimetric Assay
化学情報
-
分子量 729.33
-
分子式 C27H37F3Fe2N4O5PS
-
SMILES
C[n](C1CCCCC1)[c+]2[Fe]3([P@]4(CN5C6)CN(C5)CN6C4)([])[Fe]2(C3=O)(C=O)[].[O-]S(=O)(C(F)(F)F)=O.c7cccc7.c8cccc8
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FEACYP 関連分類
HY-161811 関連分類
Powered by Bioz