DPP3 - dipeptidyl peptidase 3 Gene

Also Known as DPPIII

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10072

About DPP3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,480,434-66,509,657 (from NCBI)

This gene has 16 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl Aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

DPP3 Products (3)

mRNA	Protein	Name
NM_001256670.2	NP_001243599.1	dipeptidyl peptidase 3 isoform 2
NM_005700.5	NP_005691.2	dipeptidyl peptidase 3 isoform 1
NM_130443.4	NP_569710.2	dipeptidyl peptidase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables dipeptidyl-peptidase activity	IDA IDA: Inferred from direct assay	9425109	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	9425109	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in proteolysis	IDA IDA: Inferred from direct assay	9425109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP3 Protein Structure

Peptidase_M49

0
200
400
600
737 a.a.

Protein Preferred Names	Protein Names
dipeptidyl peptidase 3	DPP III

DPP3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DPP3	Q9NY33	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	DPP3	Q9NY33	KEAP1	Homo sapiens	Q14145	Y2H Array	25416956
Intra	DPP3	Q9NY33	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	DPP3	Q9NY33	KEAP1	Homo sapiens	Q14145	Validated Y2H	25416956
Intra	DPP3	Q9NY33	KEAP1	Homo sapiens	Q14145	Anti Tag CoIP	33961781
Intra	DPP3	Q9NY33	KEAP1	Homo sapiens	Q14145	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPP3 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70112	Dipeptidyl peptidase 3/DPP3 Protein, Human (His)	Q9NY33 (M1-A737)	≥ 90%, as determined by reducing SDS-PAGE.

DPP3 抗体

製品番号	製品名	アプリケーション	反応性
HY-P86848	DPP3 Antibody (YA6541)	WB, IHC-P, FC	Human

関連疾患

Diseases	Alias
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Myasthenic Syndrome, Congenital, 10	Congenital Myasthenic Syndrome 10 CMS10 Lgm Myasthenia, Limb-Girdle, Familial Myasthenia, Limb-Girdle, Familial, Formerly Lgm, Formerly Congenital Myasthenic Syndrome Type Ib, Formerly Cms1b, Formerly Cms Ib, Formerly Myasthenic Myopathy, Formerly Familial Limb-Girdle Myasthenia Cms1b Cms Ib Congenital Myasthenic Syndrome Type 1b Congenital Myasthenic Syndrome Type Ib Myasthenic Myopathy Myasthenic Syndrome, Congenital, Type 10 Congenital Myasthenic Syndrome Ib Myopathy In Myasthenia Gravis
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Phase
HY-P991050	Procizumab	Inhibitor	99%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-W074143	Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride		99.78%	Unkown
HY-W127832	Ru(dpp)3(PF6)2		98.20%	Unkown
HY-RS03962	DPP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-135534	Lysine 4-nitroanilide		/	Unkown
HY-N15181	Fluostatin B	Inhibitor	/	Unkown
HY-RS18349	Dpp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24828	Dpp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P991692	Invobenitug	Inhibitor	99.10%	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	DPP3	VGNC	VGNC:61603
Rattus norvegicus	DPP3	RGD	RGD:621127
Mus musculus	DPP3	MGD	MGI:1922471
Canis familiaris	DPP3	VGNC	VGNC:40073
Bos taurus	DPP3	VGNC	VGNC:28187
Others	DPP3	NCBI