EBF1 - EBF transcription factor 1 Gene

Also Known as EBF; COE1; OLF1; O/E-1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 1879

About EBF1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:158,695,920-159,099,916 (from NCBI)

This gene has 11 transcripts (splice variants), 300 orthologues, 3 paralogues and is associated with 83 phenotypes. Broad expression in fat (RPKM 3.2), placenta (RPKM 0.8) and 17 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

EBF1 Products (15)

mRNA Protein Name
NM_001290360.3 NP_001277289.1 transcription factor COE1 isoform 1
NM_001324101.2 NP_001311030.1 transcription factor COE1 isoform 4
NM_001324103.2 NP_001311032.1 transcription factor COE1 isoform 5
NM_001324106.2 NP_001311035.1 transcription factor COE1 isoform 6
NM_001324107.2 NP_001311036.1 transcription factor COE1 isoform 7
NM_001324108.2 NP_001311037.1 transcription factor COE1 isoform 8
NM_001324109.2 NP_001311038.1 transcription factor COE1 isoform 9
NM_001324111.2 NP_001311040.1 transcription factor COE1 isoform 10
NM_001364155.2 NP_001351084.1 transcription factor COE1 isoform 11
NM_001364156.2 NP_001351085.1 transcription factor COE1 isoform 13
NM_001364157.2 NP_001351086.1 transcription factor COE1 isoform 14
NM_001364158.2 NP_001351087.1 transcription factor COE1 isoform 15
NM_001364159.2 NP_001351088.1 transcription factor COE1 isoform 16
NM_024007.5 NP_076870.1 transcription factor COE1 isoform 2
NM_182708.3 NP_874367.1 transcription factor COE1 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBF1 Protein Structure

TIG

TIG: IPT/TIG domain (262 - 344)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

transcription factor COE1

  • Collier, Olf and EBF transcription factor 1

EBF1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
Intra
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Y2H Prey Pooling
25416956
Intra
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Y2H Array
25416956
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
25416956
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
MAPPIT
32296183
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
32296183
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
32296183
Intra
EBF1 Q9UH73 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
EBF1 Q9UH73 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

EBF1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82193 EBF1 Antibody (YA1938) WB Human, Mouse

関連疾患

Diseases Alias
Plasmacytoma

  • Solitary Plasmacytoma

  • Solitary Myeloma

  • Myeloma - Solitary

  • Myeloma, Solitary

  • Plasmacytoma - Category

  • Solitary Osseous Plasmacytoma

  • Solitary Plasmacytoma Without Mention Of Remission

  • Localised Malignant Plasma Cell Tumour Nos

  • Plasmacytoma Nos
Breast Abscess

  • Abscess Of Breast
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

  • B-All With Bcr-Abl1

  • B-Lymphoblastic Leukemia/Lymphoma With T(9

  • 22)(Q34.1

  • Q11.2)

  • Bcr-Abl1

  • B Lymphoblastic Leukemia/Lymphoma With T(9

  • 22)(Q34.1

  • Q11.2)

  • Bcr-Abl1
Postpartum Depression

  • Maternity Blues

  • Postnatal Depression

  • Depression, Postpartum

  • Post-Partum Depression

  • Depression Postpartum
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

  • B-All With Iamp21

  • Intrachromosomal Amplification Of Chromosome 21
Endogenous Depression

  • Clinical Depression

  • Unipolar Depression

  • Depressive Disorder
Tetanus Neonatorum

  • Neonatal Tetanus

  • NNT

  • Trismus Neonatorum

  • Newborn Trismus
Prion Disease

  • Spongiform Encephalopathy

  • Transmissible Spongiform Encephalopathies

  • Prion Diseases

  • Prion Disease Pathway

  • Transmissible Spongiform Encephalopathy

  • Prion Induced Disorder

  • Prion Protein Disease

  • Inherited Human Transmissible Spongiform Encephalopathies

  • Prion Protein Diseases

  • Prion-Associated Disorders

  • Prion-Induced Disorders

  • Transmissible Dementias

  • Tses

  • Human Prion Disease

  • Tse

  • Encephalopathy, Transmissible Spongiform

  • Prion Disease, Susceptibility To

  • Spongiform Encephalopathies

  • Human Transmissible Spongiform Encephalopathies, Inherited
B-Lymphoblastic Leukemia/Lymphoma

  • B Lymphoblastic Leukemia/Lymphoma

  • B-All

  • Precursor B Lymphoblastic Lymphoma/Leukemia

  • C-All

  • Lymphoblastic Lymphoma, Nos

  • Common Precursor B All

  • Lymphoblastic B-Cell Lymphoma

  • Pro-B All

  • B-Precursor Lymphoma

  • Lbl - [Lymphoblastic Lymphoma]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04124 EBF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19324 Ebf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25815 Ebf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus EBF1 VGNC VGNC:50162
Macaca mulatta EBF1 VGNC VGNC:72030
Mus musculus EBF1 MGD MGI:95275
Rattus norvegicus EBF1 RGD RGD:620953
Felis catus EBF1 VGNC VGNC:61703
Canis familiaris EBF1 VGNC VGNC:40175
Others EBF1 NCBI