Nos1ap - nitric oxide synthase 1 adaptor protein Gene

Also Known as Capon

生物種: Rattus norvegicus

遺伝子タイプ: protein coding

遺伝子ID: 192363

Summary

Enables PDZ domain binding activity; nitric-oxide synthase binding activity; and protease binding activity. Involved in several processes, including neuron projection regeneration; positive regulation of peptidyl-cysteine S-nitrosylation; and regulation of calcium ion transmembrane transport. Located in cytosol and nucleus. Is active in glutamatergic synapse; postsynapse; and presynapse. Colocalizes with nuclear membrane. Used to study mental depression. Biomarker of congestive heart failure and sciatic neuropathy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Nos1ap Products (1)

mRNA	Protein	Name
NM_138922.3	NP_620277.2	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables PDZ domain binding	IDA IDA: Inferred from direct assay	9459447	RGD
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	23658158	RGD
enables nitric-oxide synthase binding	IDA IDA: Inferred from direct assay	9459447	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	11086993	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	19553464	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11086993	RGD
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	9459447	RGD

Biological Process GO Annotation	Evidence	参考文献	由来
involved in neuron projection regeneration	IEP IEP: Inferred from expression pattern	10762708	RGD
involved in positive regulation of peptidyl-cysteine S-nitrosylation	IMP IMP: Inferred from mutant phenotype	24665357	RGD
involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA IDA: Inferred from direct assay	24665357	RGD
involved in regulation of high voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	24665357	RGD

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytosol	IDA IDA: Inferred from direct assay	24665357	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20357130	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20357130	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	24665357	RGD
located in nucleus	IDA IDA: Inferred from direct assay	24665357	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	20357130	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	20357130	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	20357130	RGD
is active in presynapse	IMP IMP: Inferred from mutant phenotype	20357130	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	C-terminal PDZ domain ligand of neuronal nitric oxide synthase C-terminal PDZ ligand of neuronal nitric oxide synthase protein nitric oxide synthase 1 (neuronal) adaptor protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-124996	(Rac)-ZLc-002	Inhibitor	98.11%	Unkown
HY-RS09436	NOS1AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19265	Nos1ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25754	Nos1ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Nos1ap	NCBI	NCBI:9722