RDM1 - RAD52 motif containing 1 Gene
Also Known as RAD52B
生物種: Homo sapiens
About RDM1
This gene has 14 transcripts (splice variants), 1 gene allele and 193 orthologues. Biased expression in testis (RPKM 2.2), lymph node (RPKM 0.3) and 5 other tissues.
Summary
This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]
RDM1 Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001034836.2 | NP_001030008.1 | RAD52 motif-containing protein 1 isoform 2 |
| NM_001163120.2 | NP_001156592.1 | RAD52 motif-containing protein 1 isoform 3 |
| NM_001163121.2 | NP_001156593.1 | RAD52 motif-containing protein 1 isoform 4 |
| NM_001163122.1 | NP_001156594.1 | RAD52 motif-containing protein 1 isoform 5 |
| NM_001163124.1 | NP_001156596.1 | RAD52 motif-containing protein 1 isoform 6 |
| NM_001163125.1 | NP_001156597.1 | RAD52 motif-containing protein 1 isoform 7 |
| NM_001163130.1 | NP_001156602.1 | RAD52 motif-containing protein 1 isoform 8 |
| NM_001330194.2 | NP_001317123.1 | RAD52 motif-containing protein 1 isoform 9 |
| NM_145654.4 | NP_663629.1 | RAD52 motif-containing protein 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
RDM1 Protein Structure
RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (32 - 88)
Rad52_Rad22: Rad52/22 family double-strand break repair protein (92 - 210)
- 0
- 100
- 200
- 284 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
RAD52 motif-containing protein 1 |
|
RDM1 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
RDM1 | Q8NG50 | SCNM1 | Homo sapiens | Q9BWG6 | 32296183 | |
|
Intra
|
RDM1 | Q8NG50 | MRFAP1L1 | Homo sapiens | Q96HT8 | 25416956 | |
|
Intra
|
RDM1 | Q8NG50 | MRFAP1L1 | Homo sapiens | Q96HT8 | 25416956 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Plummer'S Disease |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | RDM1 | RGD | RGD:1310432 |
| Macaca mulatta | RDM1 | VGNC | VGNC:76778 |
| Bos taurus | RDM1 | VGNC | VGNC:33844 |
| Mus musculus | RDM1 | MGD | MGI:1913849 |
| Others | RDM1 | NCBI |