CD93 - CD93 molecule Gene
Also Known as C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
生物種: Homo sapiens
About CD93
This gene has 1 transcript (splice variant), 266 orthologues and 8 paralogues. Broad expression in placenta (RPKM 64.0), lung (RPKM 47.5) and 21 other tissues.
Summary
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the Cytoskeleton and in the remodelling of the Cytoskeleton. [provided by RefSeq, Jul 2008]
CD93 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_012072.4 | NP_036204.2 | complement component C1q receptor precursor |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables complement component C1q complex binding |
IDA
IDA: Inferred from direct assay
|
11781389 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15459234 | GOA |
| enables signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
28671670 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in angiogenesis |
IDA
IDA: Inferred from direct assay
|
28671670 | GOA |
| involved in cell-cell adhesion |
IDA
IDA: Inferred from direct assay
|
11994479 | GOA |
CD93 Protein Structure
Lectin_C: Lectin C-type domain (44 - 153)
cEGF: Complement Clr-like EGF-like (326 - 348)
EGF_CA: Calcium-binding EGF domain (385 - 425)
EGF_CA: Calcium-binding EGF domain (427 - 467)
- 0
- 100
- 200
- 300
- 400
- 500
- 600
- 652 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
complement component C1q receptor |
|
Recombinant CD93 Proteins
| 製品番号 | 製品名 | アクセッション番号 | 純度 |
|---|---|---|---|
| HY-P7691 | CD93/C1qR1 Protein, Human (HEK293, His) | Q9NPY3 (A24-K580) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78098 | CD93/C1qR1 Protein, Human (Biotinylated, HEK293, His-Avi) | Q9NPY3 (T22-K580) | ≥ 95%, as determined by Bis-Tris PAGE. |
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Felis catus | CD93 | VGNC | VGNC:80061 |
| Macaca mulatta | CD93 | VGNC | VGNC:70725 |
| Rattus norvegicus | CD93 | RGD | RGD:621251 |
| Canis familiaris | CD93 | VGNC | VGNC:58296 |
| Bos taurus | CD93 | VGNC | VGNC:52749 |
| Mus musculus | CD93 | MGD | MGI:106664 |
| Others | CD93 | NCBI |