SAMM50 - SAMM50 sorting and assembly machinery component Gene

Also Known as OMP85; SAM50; TOB55; TRG-3; CGI-51; YNL026W

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 25813

About SAMM50

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:43,955,442-43,996,529 (from NCBI)

This gene has 6 transcripts (splice variants) and 269 orthologues. Ubiquitous expression in fat (RPKM 26.2), duodenum (RPKM 21.9) and 25 other tissues.

Summary

This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]

SAMM50 Products (1)

mRNA	Protein	Name
NM_015380.5	NP_056195.3	sorting and assembly machinery component 50 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	21081504	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cristae formation	IMP IMP: Inferred from mutant phenotype	22252321	GOA
involved in mitochondrial respiratory chain complex assembly	IMP IMP: Inferred from mutant phenotype	22252321	GOA
involved in protein insertion into mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15644312	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of SAM complex	IMP IMP: Inferred from mutant phenotype	15644312	GOA
part of SAM complex	IPI IPI: Inferred from physical interaction	17510655	GOA
located in membrane	IDA IDA: Inferred from direct assay	15644312	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15644312	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15644312	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAMM50 Protein Structure

Bac_surface_Ag

0
100
200
300
400
469 a.a.

Protein Preferred Names	Protein Names
sorting and assembly machinery component 50 homolog	sorting and assembly machinery 50kDa

SAMM50 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SAMM50	Q9Y512	CHCHD6	Homo sapiens	Q9BRQ6	Y2H Prey Pooling	32296183
Intra	SAMM50	Q9Y512	MFN2	Homo sapiens	O95140	Anti Tag CoIP	27059175
Intra	SAMM50	Q9Y512	DNM1L	Homo sapiens	O00429	Anti Tag CoIP	27059175
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	25416956
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Validated Y2H	25416956
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	32296183
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	25416956
Intra	SAMM50	Q9Y512	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SAMM50 抗体

製品番号	製品名	アプリケーション	反応性
HY-P810312	SAMM50 Antibody (YA9645)	WB, IHC-P	Human
HY-P87064	SAMM50 Antibody (YA6757)	WB, IHC-P	Human, Mouse, Rat

Diseases	Alias
Glanders	Farcy Pipes Infection Due To Pseudomonas Mallei Burkholderia Mallei Burkholderia Mallei Infection Equina Equine Glanders Farcy Farcy Buds Farcy Cords Infection Due To Actinobacillus Mallei Infection Due To Malleomyces Mallei Maliasmus Malleus Farce Actinobacillosis Actinobacillus Infection
Sennetsu Fever	Sennetsu Ehrlichiosis Human Ehrlichial Infection, Sennetsu Type
Retinitis Pigmentosa 44	RP44 Retinitis Pigmentosa, Type 44
Urethral Syndrome	Urethral Disease Urethral Diseases Urethra Disease Abnormality Of The Urethra Urethral Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12434	SAMM50 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	SAMM50	VGNC	VGNC:77095
Bos taurus	SAMM50	VGNC	VGNC:34278
Canis familiaris	SAMM50	VGNC	VGNC:54542
Rattus norvegicus	SAMM50	RGD	RGD:1303219
Mus musculus	SAMM50	MGD	MGI:1915903
Others	SAMM50	NCBI