NDUFS5 - NADH:ubiquinone oxidoreductase subunit S5 Gene

Also Known as CI15K; CI-15k

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4725

About NDUFS5

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:39,026,350-39,034,615 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in heart (RPKM 174.0), fat (RPKM 138.7) and 25 other tissues.

Summary

This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]

NDUFS5 Products (2)

mRNA Protein Name
NM_001184979.2 NP_001171908.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
NM_004552.3 NP_004543.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
11112787 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
16826196 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFS5 Protein Structure

Ndufs5

Ndufs5: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa (1 - 96)

  • 0
  • 100
  • 106 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

  • CI-15 kDa

NDUFS5 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NDUFS5 O43920 SGSM1 Homo sapiens Q2NKQ1-4
Validated Y2H
32814053
Intra
NDUFS5 O43920 SGSM1 Homo sapiens Q2NKQ1-4
Y2H Array
32814053
Intra
NDUFS5 O43920 SGSM1 Homo sapiens Q2NKQ1-4
Y2H Pooling
32814053
Intra
NDUFS5 O43920 ARFGAP3 Homo sapiens Q9NP61
Y2H Array
32814053
Intra
NDUFS5 O43920 ARFGAP3 Homo sapiens Q9NP61
Y2H Pooling
32814053
Intra
NDUFS5 O43920 ARFGAP3 Homo sapiens Q9NP61
Validated Y2H
32814053
Intra
NDUFS5 O43920 SPATS1 Homo sapiens Q496A3
Validated Y2H
32814053
Intra
NDUFS5 O43920 SPATS1 Homo sapiens Q496A3
Y2H Pooling
32814053
Intra
NDUFS5 O43920 SPATS1 Homo sapiens Q496A3
Y2H Array
32814053
Intra
NDUFS5 O43920 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
NDUFS5 O43920 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
NDUFS5 O43920 HTT Homo sapiens P42858
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Mitochondrial Dna Depletion Syndrome 9

  • MTDPS9

  • Fatal Infantile Lactic Acidosis

  • Lactic Acidosis, Fatal Infantile, Formerly

  • Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria

  • Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria

  • Mitochondrial Dna Depletion Syndrome, Type 9

  • Lactic Acidosis, Fatal Infantile
Mitochondrial Complex I Deficiency, Nuclear Type 1

  • Mitochondrial Complex I Deficiency

  • Nadh:Q(1) Oxidoreductase Deficiency

  • MC1DN1

  • Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Mitochondrial Respiratory Chain Complex I Deficiency

  • Isolated Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Nadh-Coq Reductase Deficiency

  • Isolated Nadh-Ubiquinone Reductase Deficiency

  • Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

  • Nuclear Type Mitochondrial Complex I Deficiency 1

  • Isolated Complex I Deficiency

  • Complex 1 Mitochondrial Respiratory Chain Deficiency

  • Nadh Coenzyme Q Reductase Deficiency

  • Complex I Mitochondrial Respiratory Chain Deficiency

  • Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

  • Nadh:Ubiquinone Oxidoreductase Deficiency

  • Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09161 NDUFS5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21163 Ndufs5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27679 Ndufs5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus NDUFS5 RGD RGD:1311081
Mus musculus NDUFS5 MGD MGI:1890889
Canis familiaris NDUFS5 VGNC VGNC:108230
Bos taurus NDUFS5 VGNC VGNC:31970
Felis catus NDUFS5 VGNC VGNC:68446
Others NDUFS5 NCBI