Keap1 - kelch-like ECH-associated protein 1 Gene

Also Known as INRF2; mKIAA0132

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 50868

About Keap1

Chromosome 9: 21,141,026-21,150,657 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.) and 28 other tissues.

Summary

Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of Autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin Ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 Products (4)

mRNA Protein Name
NM_016679.4 NP_057888.1 kelch-like ECH-associated protein 1
NM_001110306.1 NP_001103776.1 kelch-like ECH-associated protein 1
NM_001110305.1 NP_001103775.1 kelch-like ECH-associated protein 1
NM_001110307.1 NP_001103777.1 kelch-like ECH-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
16581765 MGI
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
16581765 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
20133743 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12151510 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
9798653 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
15282312 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15087497 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
15282312 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15087497 MGI
involved in regulation of autophagy IDA
IDA: Inferred from direct assay
20173742 MGI
acts upstream of or within regulation of epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
15087497 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15282312 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
15282312 MGI
located in actin filament IDA
IDA: Inferred from direct assay
14764898 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15367669 MGI
located in cytoplasm IPI
IPI: Inferred from physical interaction
14517290 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14517290 MGI
located in inclusion body IDA
IDA: Inferred from direct assay
20173742 MGI
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
16581765 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Keap1 Protein Structure

BTB_POZ_KLHL19_KEAP1

BTB_POZ_KLHL19_KEAP1: cd18248 (55 - 179)

PHA03098

PHA03098: cl33709 (94 - 595)

Kelch

Kelch: sd00038 (361 - 408)

Kelch

Kelch: sd00038 (412 - 455)

Kelch

Kelch: sd00038 (459 - 502)

Kelch

Kelch: sd00038 (506 - 550)

Kelch

Kelch: sd00038 (553 - 596)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

kelch-like ECH-associated protein 1

  • NRF2 cytosolic inhibitor

  • cytosolic inhibitor of Nrf2

  • ring canal protein

Keap1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Cross
Keap1 Q9Z2X8 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
20173742
Intra
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
ITC
24366543
Intra
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
X-Ray Diffraction
24366543
Intra
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
Pull Down
31169361
Intra
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
Pull Down
24366543
Intra
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
TSA
24366543
Intra
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
SPR
24366543
Intra
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
X-Ray Diffraction
20173742
Intra
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
ITC
20173742
Intra
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
Anti Tag CoIP
20173742
Intra
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
Pull Down
20173742
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-W012382 N-Acetyl-L-tyrosine 99.48% Unkown

Clinical Phase

Bioactive Molecules (4)
製品番号 製品名 製品効果
純度 Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
HY-N1437 Hydroxycitric acid 99.95% Phase 2
HY-159641 VVD-130037 Activator 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (131)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-100218A RSL3 99.87% Unkown
HY-112675 4-Octyl itaconate Activator 99.92% Unkown
HY-19543 Brusatol 99.94% Unkown
HY-101140 KI696 99.26% Unkown
HY-110258 ML334 Activator 99.76% Unkown
HY-134205A CBR-470-1 Activator 98.02% Unkown
HY-113298 Citraconic acid Inhibitor 99.08% Unkown
HY-N0147 Rutaecarpine 99.77% Unkown
HY-N0005R Curcumin (Standard) 98.01% Unkown
HY-N0806 Sweroside 99.76% Unkown
HY-P2048 MOTS-c (human) 99.90% Unkown
HY-13755A (R)-Sulforaphane 99.95% Unkown
HY-P2048A MOTS-c(human) acetate Activator 99.74% Unkown
HY-N0353 Curdione Inhibitor 99.80% Unkown
HY-111126 K67 Inhibitor 98.26% Unkown
HY-N0493 Pectolinarigenin 99.98% Unkown
HY-113162 Bovinic acid ≥99.0% Unkown
HY-149508 Nrf2-IN-3 98.10% Unkown
HY-120371 CPUY192018 Inhibitor 98.90% Unkown
HY-145879 Nrf2 activator-2 Activator 99.20% Unkown
HY-W009731 Dibenzoylmethane Activator 98.0% Unkown
HY-153873 MSU38225 99.94% Unkown
HY-N0260 Epmedin C 99.47% Unkown
HY-110275 RA839 Inhibitor 98.54% Unkown
HY-103435 Vialinin A 99.90% Unkown
HY-131592 Tricetin 99.88% Unkown
HY-B0854 Mancozeb 85.50% Unkown
HY-N0005S Curcumin-d6 99.78% Unkown
HY-N0008 Orcinol glucoside 98.92% Unkown
HY-101140A KI696 isomer 98.44% Unkown
HY-171705 KMS99220 99.48% Unkown
HY-W338584 Hydroxycitric acid tripotassium 98.0% Unkown
HY-100218C (1R,3R)-RSL3 Control 99.05% Unkown
HY-139047 SW157765 Inhibitor 98.08% Unkown
HY-149010 NXPZ-2 Inhibitor 98.55% Unkown
HY-151362 Keap1-Nrf2-IN-14 Inhibitor 98.08% Unkown
HY-169766 VVD 065 Degrader 99.71% Unkown
HY-160876 BC-1901S Activator 99.81% Unkown
HY-P1328 TAT-14 Activator 99.71% Unkown
HY-162152 biKEAP1 Inhibitor 99.44% Unkown
HY-110258B (R,S,R)-ML334 Control 98.57% Unkown
HY-P10530 Nrf2 (69-84) 95.25% Unkown
HY-W012382S N-Acetyl-L-tyrosine-d3 98.44% Unkown
HY-W017187 2-tert-Butyl-1,4-benzoquinone 99.34% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-121523 MIND4-17 Activator 99.05% Unkown
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-124834 Nrf2 activator-10 98.65% Unkown
HY-146577 Keap1-Nrf2-IN-7 Inhibitor 99.82% Unkown
HY-P5909 Keap1-Nrf2 probe 98.75% Unkown
HY-P5909F FITC-labeled Keap1-Nrf2 probe 98.57% Unkown
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122054 BPK-29 99.4% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 99.19% Unkown
HY-178054 LMDP10 Activator 99.91% Unkown
HY-139620 MS83 Degrader / Unkown
HY-139620A MS83 epimer 1 98.36% Unkown
HY-113510 9(S)-HOTrE 99.9% Unkown
HY-N8160 Dehydrocurdione 97% Unkown
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112675R 4-Octyl itaconate (Standard) Activator / Unkown
HY-113162R Bovinic acid (Standard) / Unkown
HY-124941 7-Deacetylgedunin Activator / Unkown
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / Unkown
HY-139996 Pomalidomide-C5-Dovitinib Degrader / Unkown
HY-141439 TBE 31 / Unkown
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / Unkown
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / Unkown
HY-144099 Keap1-Nrf2-IN-4 / Unkown
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / Unkown
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / Unkown
HY-155997 Anti-inflammatory agent 56 Inhibitor / Unkown
HY-156065 S217879 / Unkown
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / Unkown
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / Unkown
HY-159495 Keap1-Nrf2-IN-21 / Unkown
HY-161643 S21-1011 / Unkown
HY-168065 Keap1-Nrf2-IN-22 Inhibitor / Unkown
HY-168161 Keap1-Nrf2-IN-23 Inhibitor / Unkown
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / Unkown
HY-168640 RIP3 activator 1 / Unkown
HY-168709 Nrf2 activator 18 Activator / Unkown
HY-168922 Keap1-Nrf2-IN-25 Inhibitor / Unkown
HY-169315 Nrf2 activator 17 Activator / Unkown
HY-170301 Keap1-IN-1 Inhibitor / Unkown
HY-170761 KEAP1-NRF2 PPI-IN-1 Inhibitor / Unkown
HY-171035 PRL-295 Inhibitor / Unkown
HY-172598 SG16 Inhibitor / Unkown
HY-173039 α-Tubulin polymerization-IN-1 / Unkown
HY-173181 Anticonvulsant agent 10 Inhibitor / Unkown
HY-173187 Keap1-Nrf2-IN-27 Inhibitor / Unkown
HY-174395 CD-10 / Unkown
HY-175217 Nrf2 activator-20 Activator / Unkown
HY-175548 Nrf2 activator-21 / Unkown
HY-175833 NF-κB-IN-20 / Unkown
HY-176146 Keap1/Nrf2/ARE activator 1 Activator / Unkown
HY-178873 PROTAC K-Ras Degrader-7 Degrader / Unkown
HY-179398 Keap1-Nrf2-IN-29 Inhibitor / Unkown
HY-180112 SH543 / Unkown
HY-180155 Keap1/Nrf2/ARE activator 2 / Unkown
HY-181818 4,5-Dehydro-6-oxoallosecurinine / Unkown
HY-181887 Nrf2 activator-23 / Unkown
HY-181907 NBE5 / Unkown
HY-181908 5-Norbornene-2-methylamine-C10-NH2 / Unkown
HY-183353 Nrf2 activator-25 / Unkown
HY-184204 Keap1-p-p62-IN-1 / Unkown
HY-184583 S27-1047 / Unkown
HY-184698 Nrf2/HO-1 activator 4 / Unkown
HY-184761 Keap1-Nrf2-IN-30 / Unkown
HY-N10313 Dehydrobruceine B / Unkown
HY-N17317 Isostrictiniin / Unkown
HY-N17603 Ginnalin A Activator / Unkown
HY-N19738 Obtusaquinone / Unkown
HY-P1328A TAT-14 TFA Activator / Unkown
HY-P5480 Keap1-Nrf2-IN-16 / Unkown
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W701218 Sulforaphane-d8 / Unkown
HY-112675S 4-Octyl itaconate-13C5-1 / Unkown
HY-147548 Keap1-Nrf2-IN-10 Inhibitor / Unkown
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / Unkown
HY-174287 Keap1-IN-2 Inhibitor / Unkown
HY-182927 KLHL12 ligand-1 / Unkown
HY-183448 ETMTC / Unkown
HY-184788 2-Hydroxy-5-(2-nitrovinyl)benzoic acid / Unkown
HY-N0005S1 Curcumin-d3 / Unkown
HY-N0493R Pectolinarigenin (Standard) / Unkown
HY-N11231 Fucoxanthinol / Unkown
HY-W505984 TPNA10168 Activator / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Keap1 NCBI NCBI:9817