PYGB - glycogen phosphorylase B Gene

Also Known as GPBB

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5834

About PYGB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,248,085-25,298,012 (from NCBI)

This gene has 3 transcripts (splice variants), 176 orthologues and 2 paralogues. Broad expression in colon (RPKM 67.8), heart (RPKM 66.8) and 23 other tissues.

Summary

The protein encoded by this gene is a glycogen Phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen Phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

PYGB Products (1)

mRNA Protein Name
NM_002862.4 NP_002853.2 glycogen phosphorylase, brain form

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
10638593 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYGB Protein Structure

Phosphorylase

Phosphorylase: Carbohydrate phosphorylase (112 - 830)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 843 a.a.
Protein Preferred Names Protein Names

glycogen phosphorylase, brain form

  • phosphorylase, glycogen

PYGB Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PYGB P11216 PYGL Homo sapiens P06737
Y2H Array
25416956
Intra
PYGB P11216 PYGL Homo sapiens P06737
Anti Tag CoIP
33961781
Intra
PYGB P11216 PYGL Homo sapiens P06737
Y2H Prey Pooling
25416956
Intra
PYGB P11216 PYGL Homo sapiens P06737
Validated Y2H
25416956
Intra
PYGB P11216 FKBP5 Homo sapiens Q13451
Crosslink
30021884
Intra
PYGB P11216 PYGM Homo sapiens P11217
Anti Tag CoIP
33961781
Intra
PYGB P11216 PYGM Homo sapiens P11217
Validated Y2H
32296183
Intra
PYGB P11216 PYGM Homo sapiens P11217
Y2H Array
32296183
Intra
PYGB P11216 PYGM Homo sapiens P11217
Y2H Prey Pooling
32296183
Intra
PYGB P11216 PPP1R3B Homo sapiens Q86XI6
Validated Y2H
32296183
Intra
PYGB P11216 PPP1R3B Homo sapiens Q86XI6
Anti Tag CoIP
33961781
Intra
PYGB P11216 PPP1R3B Homo sapiens Q86XI6
Y2H Array
32296183
Intra
PYGB P11216 PPP1R3B Homo sapiens Q86XI6
Y2H Prey Pooling
32296183
Intra
PYGB P11216 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra
PYGB P11216 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra
PYGB P11216 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

PYGB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P89608 PYGB/M Antibody (YA8952) WB, IP human

関連疾患

Diseases Alias
Glycogen Storage Disease Vi

  • Glycogen Storage Disease Type Vi

  • Hers Disease

  • GSD6

  • Gsd Vi

  • Hepatic Glycogen Phosphorylase Deficiency

  • Phosphorylase Deficiency Glycogen-Storage Disease Of Liver

  • Hers' Disease

  • Glycogen Storage Disease Type 6

  • Glycogen Storage Disease 6

  • Gsd Type Vi

  • Glycogenosis Type Vi

  • Glycogen Storage Disease, Type Vi

  • Hepatophosphorylase Deficiency Glycogenosis

  • Liver Phosphorylase Deficiency Syndrome

  • Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Type 6

  • Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency

  • Glycogenosis Type 6

  • Hepatic Phosphorylase Deficiency

  • Liver Glycogen Phosphorylase Deficiency

  • Her

  • Glycogen Storage Disease Vib

  • Gsd-Vi

  • Liver Phosphorylase Deficiency

  • Storage Disease, Glycogen, Type Vi
Glycogen Storage Disease Viii

  • Glycogen Storage Disease Type Viii

  • Glycogenosis Type Viii

  • Glycogen Storage Disease 8

  • Hepatic Glycogen Phosphorylase Kinase Deficiency

  • Glycogenosis Type 8

  • Hepatic Phosphorylase Kinase Deficiency

  • Pykl

  • Phosphorylase Kinase Deficiency Of Liver

  • Glycogen Storage Disease, Type Ix
Glycogen Storage Disease V

  • Mcardle Disease

  • Myophosphorylase Deficiency

  • Glycogen Storage Disease Type V

  • Muscle Glycogen Phosphorylase Deficiency

  • Pygm Deficiency

  • Gsd V

  • Glycogen Storage Disease, Type V

  • Glycogenosis Type V

  • Glycogen Storage Disease Type 5

  • GSD5

  • Pygmy

  • Mcardle'S Disease

  • Mcardle Type Glycogen Storage Disease

  • Gsd Type V

  • Pygmy, African

  • Gsdv

  • Gsd 5

  • Glycogenosis 5

  • Mcardle Syndrome

  • Muscle Phosphorylase Deficiency

  • Glycogen Storage Disease Due To Muscle Glycogen Phosphorylase Deficiency

  • Gsd Due To Muscle Glycogen Phosphorylase Deficiency

  • Gsd Type 5

  • Glycogenosis Due To Muscle Glycogen Phosphorylase Deficiency

  • Glycogenosis Type 5

  • Glycogen Storage Disease 5

  • Gsd-V

  • Mcardles Disease

  • Storage Disease, Glycogen, Type V
Glycogen Storage Disease Ixa

  • Glycogen Storage Disease Type 9a

  • Glycogen Storage Disease Type Ixa

  • Glycogenosis Type 9a

  • Glycogenosis Type Ixa

  • Gsd Type 9a

  • Gsd Type Ixa

  • Gsd9a
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Myoclonic Epilepsy Of Lafora

  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11488 PYGB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22293 Pygb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28816 Pygb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus PYGB MGD MGI:97828
Rattus norvegicus PYGB RGD RGD:3460
Felis catus PYGB VGNC VGNC:69192
Bos taurus PYGB VGNC VGNC:57019
Canis familiaris PYGB VGNC VGNC:52899
Macaca mulatta PYGB VGNC VGNC:76631
Others PYGB NCBI