PKNOX2 - PBX/knotted 1 homeobox 2 Gene

Also Known as PREP2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 63876

About PKNOX2

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,164,751-125,433,389 (from NCBI)

This gene has 14 transcripts (splice variants), 217 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues.

Summary

Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]

PKNOX2 Products (19)

mRNA	Protein	Name
NM_001382323.2	NP_001369252.1	homeobox protein PKNOX2 isoform a
NM_001382324.1	NP_001369253.1	homeobox protein PKNOX2 isoform a
NM_001382325.1	NP_001369254.1	homeobox protein PKNOX2 isoform a
NM_001382326.1	NP_001369255.1	homeobox protein PKNOX2 isoform a
NM_001382327.1	NP_001369256.1	homeobox protein PKNOX2 isoform a
NM_001382328.1	NP_001369257.1	homeobox protein PKNOX2 isoform a
NM_001382329.1	NP_001369258.1	homeobox protein PKNOX2 isoform b
NM_001382330.1	NP_001369259.1	homeobox protein PKNOX2 isoform b
NM_001382331.1	NP_001369260.1	homeobox protein PKNOX2 isoform b
NM_001382332.1	NP_001369261.1	homeobox protein PKNOX2 isoform b
NM_001382333.1	NP_001369262.1	homeobox protein PKNOX2 isoform b
NM_001382334.1	NP_001369263.1	homeobox protein PKNOX2 isoform c
NM_001382335.1	NP_001369264.1	homeobox protein PKNOX2 isoform c
NM_001382336.1	NP_001369265.1	homeobox protein PKNOX2 isoform d
NM_001382337.1	NP_001369266.1	homeobox protein PKNOX2 isoform d
NM_001382338.1	NP_001369267.1	homeobox protein PKNOX2 isoform d
NM_001382339.1	NP_001369268.1	homeobox protein PKNOX2 isoform e
NM_001382340.1	NP_001369269.1	homeobox protein PKNOX2 isoform f
NM_001382341.1	NP_001369270.1	homeobox protein PKNOX2 isoform g

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKNOX2 Protein Structure

Homeobox_KN

0
100
200
300
400
472 a.a.

Protein Preferred Names	Protein Names
homeobox protein PKNOX2	PBX/knotted homeobox 2

PKNOX2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	PKNOX2	Q96KN3	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	CTTNBP2NL	Homo sapiens	Q9P2B4	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	DDA1	Homo sapiens	Q9BW61	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	PBX1	Homo sapiens	P40424	Anti Tag CoIP	33961781
Intra	PKNOX2	Q96KN3	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	PAAT	Homo sapiens	Q9H8K7	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	CSTF2T	Homo sapiens	Q9H0L4	Validated Y2H	32296183
Intra	PKNOX2	Q96KN3	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a	MLC2A Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a
Brugada Syndrome 2	BRGDA2 Brugada Syndrome, Type 2
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b	Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS10610	PKNOX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	PKNOX2	VGNC	VGNC:44615
Felis catus	PKNOX2	VGNC	VGNC:64196
Bos taurus	PKNOX2	VGNC	VGNC:32949
Rattus norvegicus	PKNOX2	RGD	RGD:1590611
Macaca mulatta	PKNOX2	VGNC	VGNC:76037
Mus musculus	PKNOX2	MGD	MGI:2445415
Others	PKNOX2	NCBI