IKZF4 - IKAROS family zinc finger 4 Gene

Also Known as EOS; ZNFN1A4

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 64375

About IKZF4

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,007,504-56,038,435 (from NCBI)

This gene has 13 transcripts (splice variants), 261 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 4.5), testis (RPKM 3.7) and 25 other tissues.

Summary

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

IKZF4 Products (5)

mRNA	Protein	Name
NM_001351089.2	NP_001338018.1	zinc finger protein Eos isoform a
NM_001351090.1	NP_001338019.1	zinc finger protein Eos isoform b
NM_001351091.2	NP_001338020.1	zinc finger protein Eos isoform c
NM_001351092.2	NP_001338021.1	zinc finger protein Eos isoform d
NM_022465.4	NP_071910.3	zinc finger protein Eos isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15491138	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15491138	GOA
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	15491138	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in protein homooligomerization	IMP IMP: Inferred from mutant phenotype	15491138	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15491138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKZF4 Protein Structure

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
585 a.a.

Protein Preferred Names	Protein Names
zinc finger protein Eos	ikaros family zinc finger protein 4

IKZF4 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	IKZF4	Q9H2S9	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	IKZF4	Q9H2S9	MOB1A	Homo sapiens	Q9H8S9	Validated Y2H	32296183
Intra	IKZF4	Q9H2S9	MOB3C	Homo sapiens	Q70IA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-173630	BMS-986449	Inhibitor	/	Phase 2

Pre-clinical Phase