EBF2 - EBF transcription factor 2 Gene

Also Known as COE2; OE-3; EBF-2; O/E-3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 64641

About EBF2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,841,725-26,045,413 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 3 paralogues. Biased expression in fat (RPKM 8.6), heart (RPKM 4.4) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]

EBF2 Products (1)

mRNA Protein Name
NM_022659.4 NP_073150.2 transcription factor COE2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBF2 Protein Structure

TIG

TIG: IPT/TIG domain (253 - 335)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 575 a.a.
Protein Preferred Names Protein Names

transcription factor COE2

  • Collier, Olf and EBF 2

EBF2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
EBF2 Q9HAK2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
EBF2 Q9HAK2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
EBF2 Q9HAK2 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
EBF2 Q9HAK2 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Inguinal Hernia

  • Hernia Inguinal

  • Hernia, Inguinal

  • Inguinal Hernias

  • Bubonocele

  • Indirect Inguinal Hernia

  • Direct Inguinal Hernia

  • Oblique Inguinal Hernia

  • Scrotal Hernia

  • Ih - [Inguinal Hernia]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04125 EBF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus EBF2 RGD RGD:1310805
Felis catus EBF2 VGNC VGNC:61704
Bos taurus EBF2 VGNC VGNC:106720
Mus musculus EBF2 MGD MGI:894332
Canis familiaris EBF2 VGNC VGNC:40176
Macaca mulatta EBF2 VGNC VGNC:83996
Others EBF2 NCBI