UBE2H - ubiquitin conjugating enzyme E2 H Gene

Also Known as GID3; UBC8; UBCH; UBCH2; E2-20K

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7328

About UBE2H

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:129,830,732-129,952,960 (from NCBI)

This gene has 10 transcripts (splice variants), 214 orthologues and 24 paralogues. Ubiquitous expression in heart (RPKM 38.0), adrenal (RPKM 36.4) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

UBE2H Products (3)

mRNA Protein Name
NM_001202498.2 NP_001189427.1 ubiquitin-conjugating enzyme E2 H isoform 3
NM_003344.4 NP_003335.1 ubiquitin-conjugating enzyme E2 H isoform 1
NM_182697.3 NP_874356.1 ubiquitin-conjugating enzyme E2 H isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
20028976 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2H Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (29 - 144)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 H

  • (E3-independent) E2 ubiquitin-conjugating enzyme H

UBE2H Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
UBE2H P62256 GNB2 Homo sapiens P62879
Y2H Array
32814053
Intra
UBE2H P62256 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Intra
UBE2H P62256 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
UBE2H P62256 MAGEA2 Homo sapiens P43356
Pull Down
20864041
Intra
UBE2H P62256 MAGEC2 Homo sapiens Q9UBF1
Anti Tag CoIP
20864041
Intra
UBE2H P62256 MAGEC2 Homo sapiens Q9UBF1
Ubiquitinase Assay
20864041
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2H Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71402 UBE2H Protein, Human (GST) P62256 (M1-L183) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15348 UBE2H Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20122 Ube2h Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26626 Ube2h Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris UBE2H VGNC VGNC:48054
Rattus norvegicus UBE2H RGD RGD:2319288
Macaca mulatta UBE2H VGNC VGNC:78696
Mus musculus UBE2H MGD MGI:104632
Bos taurus UBE2H VGNC VGNC:36583
Others UBE2H NCBI